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Linaclotide

Linaclotide Suppliers list
Company Name: AFINE CHEMICALS LIMITED
Tel: 008657185134551
Email: info@afinechem.com
Products Intro: Product Name:LINACLOTIDE
CAS:851199-59-2
Purity:98%+ Package:Standard or custom package Remarks:excellent quality and reliable supplier
Company Name: Hangzhou Go Top Peptide Biotech
Tel: 0571-88211921
Email: sales1@gotopbio.com
Products Intro: Product Name:Linaclotide
CAS:851199-59-2
Purity:98% HPLC、MS Package:1mg/ plastic bottle ,customer's requirement packaging also welcome
Company Name: Alpha Biopharmaceuticals Co., Ltd
Tel: 0086-411-39042497
Email: sales@alphabiopharm.com
Products Intro: Product Name:Linaclotide
CAS:851199-59-2
Purity:99% HPLC Package:25mg; 50mg;250mg;Bulk
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
Email: info@dakenchem.com
Products Intro: Product Name:Linaclotide
CAS:851199-59-2
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:851199-59-2
Purity:99% Package:500G;1KG;5KG;25KG

Linaclotide manufacturers

  • Linaclotide
  • $2270.00 / g
  • 2021-11-30
  • CAS:851199-59-2
  • Min. Order: 1g
  • Purity: 98%
  • Supply Ability: 1-20mt
  • Linaclotide
  • $0.00 / Kg/Bag
  • 2021-11-09
  • CAS:851199-59-2
  • Min. Order: 2Kg/Bag
  • Purity: 98% up
  • Supply Ability: 20 tons
  • Linaclotide
  • $15.00-10.00 / KG
  • 2021-07-13
  • CAS:851199-59-2
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
Linaclotide Basic information
Product Name:Linaclotide
Synonyms:Linacllotide;Linaclotide;Linaelotide Acetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1→6),(2→10),(5→13)-tris(disulfide)
CAS:851199-59-2
MF:C59H79N15O21S6
MW:1526.74
EINECS:
Product Categories:Inhibitors
Mol File:851199-59-2.mol
Linaclotide Structure
Linaclotide Chemical Properties
Boiling point 2045.0±65.0 °C(Predicted)
density 1.60
pka3.05±0.10(Predicted)
Safety Information
Hazardous Substances Data851199-59-2(Hazardous Substances Data)
MSDS Information
Linaclotide Usage And Synthesis
DescriptionIn August 2012, the US FDA approved linaclotide (also referred to as MD-1100), a first-in-class, orally administered 14-amino acid peptide as a therapy for patients suffering from chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). Linaclotide and its active metabolite MM-419447, which results from the cleavage of the C-terminal tyrosine residue by carboxypeptidase A, mimic the actions of the endogenous intestinal peptides guanylin (15 amino acids) and uroguanylin (16 amino acids) by activating guanylyl cyclase C (GC-C) on the intestinal epithelium. Activation of GC-C leads to increased intra- and extracellular levels of cGMP and activation of the CFTR ion channel, resulting in increased levels of HCO3-, Cl-, and water in the intestinal lumen and accelerated gastrointestinal transit. Based on an in vitro assaymeasuring the accumulation of cGMP in T84 cell exposed to an agonist, the EC50 of linaclotide at pH 7.0 was 99±17.5 nM. In preclinical studies in mice using the transit of activated charcoal as ameasure of efficacy, linaclotide at 100 μg/kg significantly accelerated transit compared to wild-type mice treated with charcoal only or GC-Cnullmice treatedwith and without linaclotide.118 Efficacy was also seen in rats treatedwith linaclotide atdoses of 5, 10, and 20 μg/kg. Linaclotide has been synthesized using conventional solid-phase peptide technology.
OriginatorIronwood Pharmaceuticals and Forest Pharmaceuticals (United States)
Brand nameLinzess
Linaclotide Preparation Products And Raw materials
Tag:Linaclotide(851199-59-2) Related Product Information
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