- JNJ-5207852
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- $30.00 / 5mg
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2025-11-09
- CAS:398473-34-2
- Min. Order:
- Purity: 97.19%
- Supply Ability: 10g
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| | JNJ 5207852 dihydrochloride Basic information |
| Product Name: | JNJ 5207852 dihydrochloride | | Synonyms: | JNJ 5207852 dihydrochloride;JNJ 5207852;Piperidine, 1-[3-[4-(1-piperidinylmethyl)phenoxy]propyl]-;1-[3-[4-(1-Piperidinylmethyl)phenoxy]propyl]piperidine hydrochloride;1-{3-[4-(PIPERIDIN-1-YLMETHYL)PHENOXY]PROPYL}PIPERIDINE;1-(4-(3-piperidin-1-ylpropoxy)benzyl)piperidine;sleep,low,JNJ5207852,Histamine Receptor,JNJ-5207852,JNJ 5207852,Inhibitor,REM,toxicity,inhibit;JNJ-5207852, 10 mM in DMSO | | CAS: | 398473-34-2 | | MF: | C20H32N2O | | MW: | 316.48 | | EINECS: | | | Product Categories: | Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals | | Mol File: | 398473-34-2.mol |  |
| | JNJ 5207852 dihydrochloride Chemical Properties |
| Boiling point | 443.4±30.0 °C(Predicted) | | density | 1.032±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO : 77.5 mg/mL (244.88 mM; Need ultrasonic) | | form | Powder | | pka | 9.70±0.10(Predicted) | | color | Light yellow to yellow |
| | JNJ 5207852 dihydrochloride Usage And Synthesis |
| Uses | JNJ 5207852 is a Histamine H3 Receptor antagonist, used in the treatment of obesity. | | in vivo | JNJ-5207852 (1-10mg/kg s.c.) increases time spent awake and decreases REM sleep and slow-wave sleep, but fails to have an effect on wakefulness or sleep in H3 receptor knockout mice. The wake promoting effects of this H3 receptor antagonist are not associated with hypermotility. A 4-week daily treatment of mice with JNJ-5207852 (10 mg/kg i.p.) does not lead to a change in body weight. JNJ-5207852 is extensively absorbed after oral administration and reaches high brain levels[1]. | Animal Model: | Male, Sprague-Dawley rats weighing 282-334 g[1].
| | Dosage: | 3, 10, 30 mg/kg. | | Administration: | S.C. | | Result: | Iincreased time spent awake and decreased REM sleep and slow-wave sleep. |
| | IC 50 | H3 receptor: 8.9 (pKi, for rat); H3 receptor: 9.24 (pKi, for human) |
| | JNJ 5207852 dihydrochloride Preparation Products And Raw materials |
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