- Pteroic Acid
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- $10.00 / 10g/Bag
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2021-12-14
- CAS:119-24-4
- Min. Order: 10g
- Purity: 99
- Supply Ability: 100KG
- Pteroic Acid
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- $100.00 / 1KG
-
2021-05-08
- CAS:119-24-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1000t
- PTEROIC ACID
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- $2.00 / 1KG
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2019-07-06
- CAS:119-24-4
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1ton
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| | PTEROIC ACID Basic information |
| | PTEROIC ACID Chemical Properties |
| Melting point | >400℃ | | Boiling point | 610.0±65.0 °C(Predicted) | | density | 1.69 | | storage temp. | 2-8°C | | solubility | Aqueous Base (Slightly), DMSO (Slightly) | | pka | 4.65±0.10(Predicted) | | color | Light Yellow to Brown |
| WGK Germany | 3 | | HS Code | 2933599590 |
| | PTEROIC ACID Usage And Synthesis |
| Uses | Pteroic Acid (Methotrexate EP Impurity D N-Desmethyl Impurity) is a constituent as well as a degradation product of Folic Acid (F680300) formed via enzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutamate synthetase. | | Uses | Pteroic Acid is a constituent as well as a degradation product of Folid Acid (F680300) formed via anzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutama
te synthetase. | | Definition | ChEBI: 4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoic acid is a pteroic acid. It is functionally related to a 2-aminopteridin-4-ol. It is a conjugate base of a 2-amino-6-{[(4-carboxyphenyl)amino]methyl}-4-hydroxypteridin-1-ium. It is a conjugate acid of a 4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoate. It is a tautomer of a 4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoic acid and a 4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoic acid. | | General Description | Folic Acid Impurity D is an impurity of the water-soluble B-vitamin, folic acid. Folic Acid is generally used in the treatment of certain types of anemia.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. | | Enzyme inhibitor | This metabolite (FWfree-acid = 312.29 g/mol; CAS 119-24-4), also known as 4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoic acid, is a structural component of folates. Pteroic acid is a growth factor for a number of Enterococci. Pteroic acid is a yellow powder that is slightly soluble in aqueous NaOH. The lmax values in 0.1 M NaOH are 255, 275, and 365 nm (e = 26300, 23400, and 8900 M–1cm–1, respectively). Target(s): arylamine N-acetyltransferase; dihydrofolate reductase; dihydrofolate synthetase, weakly inhibited; dihydropteroate synthase; glutamate carboxypeptidase; and xanthine oxidase. | | Purification Methods | Crystallise it from dilute HCl. Dry it in vacuo. Hygroscopic IRRITANT. [Nair et al. J Org Chem 46 3152 1981, Beilstein 26 III/IV 3942.] |
| | PTEROIC ACID Preparation Products And Raw materials |
| Raw materials | AcetaMide, 2,2,2-trifluoro-N-(4-iodophenyl)--->N10-Trifluoroacetyl Pyrofolic Acid-->4-[(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)methylamino]benzoic acid-->DL-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]--->CHEMBRDG-BB 5276151-->Folic acid-->6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE-->4-Aminobenzoic acid | | Preparation Products | Benzoic acid, 4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]-, 2,5-dioxo-1-pyrrolidinyl ester |
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