- Tosyl isocyanate
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- $0.00 / 1Kg
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2024-04-08
- CAS:4083-64-1
- Min. Order: 1Kg
- Purity: 99.9%
- Supply Ability: 200tons
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| | p-Toluenesulfonyl Isocyanate Basic information |
| | p-Toluenesulfonyl Isocyanate Chemical Properties |
| Hazard Codes | Xn | | Risk Statements | 14-36/37/38-42 | | Safety Statements | 26-28-30-28A | | RIDADR | UN 2206 6.1/PG 3 | | WGK Germany | 1 | | RTECS | DB9032000 | | F | 10 | | TSCA | Yes | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29309090 |
| | p-Toluenesulfonyl Isocyanate Usage And Synthesis |
| Chemical Properties | clear liquid | | Uses | It is a reagent used to prepare acetylated syn-1,2-diols,oxazolidin-2-ones, 2,3-diamino acids, and N-tosylcarbonamides. -Toluenesulfonyl isocyanate has been used as derivatization reagent in determination of 3-α-hydroxy tibolone in human plasma by LC-MS/MS. It is also employed in the derivatization reagent in simultaneous quantitative analysis of diethylene glycol and propylene glycol in pharmaceutical products by HPLC and as reagent in the preparation of acetylated syn-1,2-diols, oxazolidin-2-ones, 2,3-diamino acids and N-tosylcarbonamides. | | Uses | p-Toluenesulfonyl isocyanate is a reagent used to prepare acetylated syn-1,2-diols,1 oxazolidin-2-ones,2 2,3-diamino acids,3 and N-tosylcarbonamides.4 | | Synthesis Reference(s) | Tetrahedron Letters, 35, p. 9609, 1994 DOI: 10.1016/0040-4039(94)88523-0 | | General Description | p-Toluenesulfonyl isocyanate undergoes palladium-catalyzed bis-allylation reaction with allylstannanes and allyl chlorides. | | Hazard | Moderately toxic by ingestion. Low toxicity by inhalation. A mild skin and moderate eye
irritant. | | Synthesis | Add the organic azide (0.75 mmol), Pd(OAc)2
(5.6 mg, 5 mol%) to an oven-dried Schlenk tube (10 mL). Purge the tube
and backfill with CO (three cycles) from a balloon. Inject anhydrous
MeCN (3.0 mL) into the tube. Stir at 80??C for 4 h under CO atmosphere
(balloon). Concentrate the mixture under reduced pressure. Purify the
residue by column chromatography (petroleum ether/EtOAc 3:1.-.1:1).
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| | p-Toluenesulfonyl Isocyanate Preparation Products And Raw materials |
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