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Yichang Zhongyitai Trading Co., Ltd.
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Product Name:17(S)-Hydroxy-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid
CAS:92693-03-3
Purity:98+% Package:100ug
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| Company Name: |
Alfa Chemistry
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1-516-6625404 |
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Product Name:17(S)-hydroxy-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid
CAS:92693-03-3
Purity:98%+ Package:1g;10g;100g;1KG;5KG
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| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 |
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sales@glpbio.cn |
| Products Intro: |
Product Name:17(S)-HDHA
CAS:92693-03-3
Purity:>98% Package:1mg;10mg;50mg;100mg;
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:17(S)-HDHA
CAS:92693-03-3
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | 17(S)-HDoHE Basic information |
| Product Name: | 17(S)-HDoHE | | Synonyms: | 17(S)-HDoHE;SWTYBBUBEPPYCX-YTQNUIGOSA-N;17(S)-HDHA;4,7,10,13,15,19-Docosahexaenoic acid, 17-hydroxy-, (4Z,7Z,10Z,13Z,15E,17S,19Z)-;17(S)-hydroxy-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid;17(S)HDHA,17(S) HDHA | | CAS: | 92693-03-3 | | MF: | C22H32O3 | | MW: | 344.49 | | EINECS: | | | Product Categories: | | | Mol File: | 92693-03-3.mol |  |
| | 17(S)-HDoHE Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml |
| | 17(S)-HDoHE Usage And Synthesis |
| Description | 17(S)-HDHA is a hydroxy fatty acid formed from docosahexaenoic acid (DHA; ) by 15-lipoxygenase (15-LO) and is a precursor to 17(S)-resolvins.1,2 17(S)-HDHA inhibits platelet 12-LO (IC50 = 0.4 μM).2 It inhibits TNF-α-induced expression of IL1B in a human glial cell line (IC50 = ~0.5 nM).1 17(S)-HDHA (100 nM) inhibits NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome formation induced by homocysteine in podocytes.3 | | Definition | ChEBI: 17(S)-HDoHE is a polyunsaturated fatty acid that is (4Z,7Z,10Z,13Z,15E,19Z)-docosa-4,7,10,13,15,19-hexaenoic acid carrying a hydroxy substituent at the 17S-position. It is a metabolite of docosahexaenoic acid in human blood and mouse brain, and serves as a precursor to 17(S)-resolvins. It has a role as a mouse metabolite, an animal metabolite and a human xenobiotic metabolite. It is an enantiomer of a 17(R)-HDoHE. | | References | 1. Hong, S., Gronert, K., Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation J. Biol. Chem. 278(17),14677-14687(2003).
2. Mitchell, P.D., Hallam, C., Hemsley, P.E., et al. Inhibition of platelet 12-lipoxygenase by hydroxy-fatty acids Biochem. Soc. Trans. 12,839-841(1984).
3. Li, G., Chen, Z., Bhat, O.M., et al. NLRP3 inflammasome as a novel target for docosahexaenoic acid metabolites to abrogate glomerular injury J. Lipid Res. 58(6),1080-1090(2017). |
| | 17(S)-HDoHE Preparation Products And Raw materials |
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