| Company Name: |
Yichang Zhongyitai Trading Co., Ltd.
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| Tel: |
0717-6449896 13886658719 |
| Email: |
root@zhongyitai.com |
| Products Intro: |
Product Name:17(S)-Hydroxy-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid
CAS:92693-03-3
Purity:98+% Package:100ug
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| Company Name: |
Shanghai Macklin Biochemical Co.,Ltd.
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| Tel: |
15221275939 |
| Email: |
shenlinxing@macklin.cn |
| Products Intro: |
Product Name:17(S)-HDHA
CAS:92693-03-3
Purity:98%， 100 μg/mL in Ethanol Package:100μg
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| Company Name: |
Alfa Chemistry
|
| Tel: |
1-516-6625404 |
| Email: |
support@alfa-chemistry.com |
| Products Intro: |
Product Name:17(S)-hydroxy-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid
CAS:92693-03-3
Purity:98%+ Package:1g;10g;100g;1KG;5KG
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17(S)-HDoHE manufacturers
- 17(S)-HDHA
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- $1360.00 / 250μg
-
2024-10-28
- CAS:92693-03-3
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 17(S)-HDoHE Basic information |
| Product Name: | 17(S)-HDoHE | | Synonyms: | 17(S)-HDoHE;SWTYBBUBEPPYCX-YTQNUIGOSA-N;17(S)-HDHA;4,7,10,13,15,19-Docosahexaenoic acid, 17-hydroxy-, (4Z,7Z,10Z,13Z,15E,17S,19Z)-;17(S)-hydroxy-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid;17(S)HDHA,17(S) HDHA;17(S)-Hydroxy-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-DHA | | CAS: | 92693-03-3 | | MF: | C22H32O3 | | MW: | 344.49 | | EINECS: | | | Product Categories: | | | Mol File: | 92693-03-3.mol |  |
| | 17(S)-HDoHE Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml | | form | ethanol solution |
| | 17(S)-HDoHE Usage And Synthesis |
| Description | 17(S)-HDHA is a hydroxy fatty acid formed from docosahexaenoic acid (DHA; ) by 15-lipoxygenase (15-LO) and is a precursor to 17(S)-resolvins.1,2 17(S)-HDHA inhibits platelet 12-LO (IC50 = 0.4 μM).2 It inhibits TNF-α-induced expression of IL1B in a human glial cell line (IC50 = ~0.5 nM).1 17(S)-HDHA (100 nM) inhibits NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome formation induced by homocysteine in podocytes.3 | | Uses | 17(S)-HDHA is a pro-resolving mediator (SPM). 17(S)-HDHA slightly activats PPARγ, PPARα and PPARδ[1]. | | Definition | ChEBI: 17(S)-HDoHE is a polyunsaturated fatty acid that is (4Z,7Z,10Z,13Z,15E,19Z)-docosa-4,7,10,13,15,19-hexaenoic acid carrying a hydroxy substituent at the 17S-position. It is a metabolite of docosahexaenoic acid in human blood and mouse brain, and serves as a precursor to 17(S)-resolvins. It has a role as a mouse metabolite, an animal metabolite and a human xenobiotic metabolite. It is an enantiomer of a 17(R)-HDoHE. | | References | 1. Hong, S., Gronert, K., Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation J. Biol. Chem. 278(17),14677-14687(2003).
2. Mitchell, P.D., Hallam, C., Hemsley, P.E., et al. Inhibition of platelet 12-lipoxygenase by hydroxy-fatty acids Biochem. Soc. Trans. 12,839-841(1984).
3. Li, G., Chen, Z., Bhat, O.M., et al. NLRP3 inflammasome as a novel target for docosahexaenoic acid metabolites to abrogate glomerular injury J. Lipid Res. 58(6),1080-1090(2017). |
| | 17(S)-HDoHE Preparation Products And Raw materials |
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