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| CAY10526 Basic information |
Product Name: | CAY10526 | Synonyms: | CAY10526;CAY10526 Exclusive;3-(1-benzothiophen-2-yl)-4-bromo-2-hydroxy-2H-furan-5-one;2(5H)-Furanone, 4-benzo[b]thien-2-yl-3-bromo-5-hydroxy-;WM793,PGE2 production,Inhibitor,inhibit,SB2,microsomal PGE2 synthase-1,A375,cleaved caspase 3,CAY10526,increases apoptosis,increases BAX and BAK,pro-apoptotic,anti-apoptotic,melanoma xenografts,mPGES1 inhibitor,PGE synthase,Prostaglandin E synthase;4-(Benzo[b]thiophen-2-yl)-3-bromo-5-hydroxyfuran-2(5H)-one | CAS: | 938069-71-7 | MF: | C12H7BrO3S | MW: | 311.15 | EINECS: | | Product Categories: | | Mol File: | 938069-71-7.mol | |
| CAY10526 Chemical Properties |
Boiling point | 561.7±50.0 °C(Predicted) | density | 1.889±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml | form | A crystalline solid | pka | 8.90±0.60(Predicted) |
| CAY10526 Usage And Synthesis |
Description | Prostaglandin E2 (PGE2) is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases. It acts as a mediator of pain and inflammation and promotes bone destruction. The increased synthesis of PGE2 during inflammation can be accounted for by increased expression of both cyclooxygenase-2 (COX-2) and microsomal PGE synthase-1 (mPGES-1). CAY10526 is an inhibitor of PGE2 production through the selective modulation of mPGES-1 expression. It dose-dependently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells with an IC50 value of 1.8 μM without any effect on COX-2 expression. |
| CAY10526 Preparation Products And Raw materials |
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