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| | (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid Basic information |
| Product Name: | (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid | | Synonyms: | (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid;Ticagrelor Related Compound 28;Ticagerelor Impurity;Ticagrelor-22;Ticagrelor impurity 33/(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid;Cyclopropanecarboxylic acid, 2-(3,4-difluorophenyl)-, (1R,2R)-;(1R-2R)-2-(3,4-DIFLUOROPHENYL)CYCLOPROPANECARBOXYLIC ACID CAS 220352-36-3;(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid | | CAS: | 220352-36-3 | | MF: | C10H8F2O2 | | MW: | 198.17 | | EINECS: | 1533716-785-6 | | Product Categories: | | | Mol File: | 220352-36-3.mol |  |
| | (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid Chemical Properties |
| Melting point | 78 - 81°C | | Boiling point | 308.1±42.0 °C(Predicted) | | density | 1.435±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly) | | pka | 4.53±0.10(Predicted) | | form | Solid | | color | Off-White |
| | (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid Usage And Synthesis |
| Uses | (1R,2R)-2-(3,4-Difluorophenyl)-cyclopropanecarboxylic Acid is an intermediate used to prepare AZD6140 as an orally active reversible P2Y12 receptor antagonist for prevention of thrombosis. It is also used to synthesize triazolopyrimidine derivatives as P2T receptor antagonists. |
| | (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid Preparation Products And Raw materials |
| Raw materials | 3,4-difluorocinnaMoyl chloride-->trans-3,4-Difluorocinnamic acid-->2-Chloro-1-(3,4-difluoro-phenyl)-ethanone-->3,4-Difluorophenylboronic acid-->(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarbonitrile-->(1R,2R)-ethyl2-(3,4-difluorophenyl)cyclopropane carboxylate-->3,4-DIFLUOROSTYRENE-->(1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol-->1,2-Difluoro-4-iodobenzene-->1,2-Difluorobenzene-->Cyclopropanecarboxylic acid-->3,4-Difluorobenzaldehyde-->Triethyl phosphonoacetate | | Preparation Products | (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide-->(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate |
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