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Cilastatin sodium

Cilastatin sodium Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Purity:98% Package:10MG;50MG;100MG,1G,5G,10G
Company Name: Standardpharm Co. Ltd.
Tel: 86-714-3992388
Email: overseasales1@yongstandards.com
Products Intro: Product Name:Cilastatin Impurity 9
CAS:81129-83-1
Purity:0.99 Package:10mg;25mg;50mg;100mg
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:Cilastatin sodium
CAS:81129-83-1
Purity:>=99% by HPLC Package:1g Remarks:BOC Sciences also provides custom synthesis services for Cilastatin sodium.
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:cilastatin sodium
CAS:81129-83-1
Purity:0.99 Package:1kg
Company Name: career henan chemical co
Tel: +86-0371-86658258 15093356674;
Email: factory@coreychem.com
Products Intro: Product Name:Cilastatin sodium
CAS:81129-83-1
Purity:99% Package:1KG;1USD

Cilastatin sodium manufacturers

  • Cilastatin Sodium
  • Cilastatin Sodium pictures
  • $11.00 / 1g
  • 2024-03-20
  • CAS:81129-83-1
  • Min. Order: 1g
  • Purity: 98%HPLC
  • Supply Ability: 20KG
  • Cilastatin sodium
  • Cilastatin sodium pictures
  • $0.00 / 1KG
  • 2023-01-30
  • CAS:81129-83-1
  • Min. Order: 1KG
  • Purity: 98%min
  • Supply Ability: 30tons/month
  • Cilastatin sodium
  • Cilastatin sodium pictures
  • $1.00 / 1KG
  • 2020-02-18
  • CAS:81129-83-1
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 200kgs
Cilastatin sodium Basic information
Product Name:Cilastatin sodium
Synonyms:Cilastatine;Cilastatin sodium;Sodium 7-(2-amino-2-carboxy-ethyl)sulfanyl-2-(2,2-dimethylcyclopropyl)carbonylamino-hept-2-enoate;Sodium hydrogen 7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoate;Sodium Cilastatin;[R-[R*,S*-(Z)]]-7-[(2-Amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-2-heptenoic acid monosodium salt;(Z)-7-[(R)-2-Amino-2-carboxyethylthio]-2-[(S)-2,2-dimethylcyclopropylcarbonylamino]-2-heptenoic acid 1-sodium salt;(2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoicacidsodiumsalt
CAS:81129-83-1
MF:C16H25N2O5S.Na
MW:380.44
EINECS:279-694-4
Product Categories:Miscellaneous Enzyme;APIs
Mol File:81129-83-1.mol
Cilastatin sodium Structure
Cilastatin sodium Chemical Properties
Melting point >160°C (dec.)
Fp 87℃
storage temp. 2-8°C
solubility Very soluble in water and in methanol, slightly soluble in anhydrous ethanol, very slightly soluble in dimethyl sulfoxide, practically insoluble in acetone and in methylene chloride.
pkapKa1 2.0; pKa2 4.4; pKa3 9.2(at 25℃)
color White
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
CAS DataBase Reference81129-83-1(CAS DataBase Reference)
Safety Information
RTECS MJ9650200
HS Code 2941.90.1050
MSDS Information
Cilastatin sodium Usage And Synthesis
DescriptionCilastatin Na (81129-83-1) is a dehydropeptidase-1 inhibitor. Inhibits the proteolytic conversion of leukotriene D4?to E4.1? Inhibits the mammalian β-lactamase renal dipeptidase (dehydropeptidase-1, DPEP1) and thus is used as an antibacterial adjunct to extend the half-life of β-lactam antibiotics.2?Cilastatin also inhibits bacterial metallo-β-lactamase and thereby may block resistance to the carbapenem family of antibiotics in certain bacteria.3? Suppresses invasion and metastasis of DPEP1-expressing tumor cells.4
Chemical PropertiesWhite or light yellow amorphous, hygroscopic powder.
UsesEnzyme inhibitor.
UsesCilastatin sodium is a dipeptidase inhibitor with nephroprotective effects.
DefinitionChEBI: The monosodium salt of cilastatin. It is an inhibitor of dehydropeptidase I (membrane dipeptidase, 3.4.13.19), an enzyme found in the brush border of renal tubes and responsible for degrading the antibiotic imipenem. Cilastatin sodium is therefore administ red with imipenem to prolong the antibacterial effect of the latter by preventing its renal metabolism to microbiologically inactive and potentially nephrotoxic products.
General DescriptionCilastatin sodium salt is off-white to yellowish-white, hygroscopic, amorphous compound. It is derivatized from heptenoic acid. Its molecular mass is 380.43 g.
Biological ActivityDipeptidase inhibitor (LTDase, leukotriene D4 hydrolase, dehydropeptidase I) that displays a K i value of 0.11 μ M. Inhibits metabolism of LTD 4 to LTE 4 and the hydrolysis of β -lactam antibiotics. Nephroprotective; reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells.
Biochem/physiol ActionsInhibitor of the renal enzyme dehydropeptidase I and some bacterial zinc-containing β-lactamases. By these action, cilastatin suppresses both host and target metabolism of the broad-spectrum antibiotic imipenem, improving its efficacy.
References1) White?et al.?(1999),?A continuous fluorometric assay for Leukotriene D4 hydrolase; Anal. Biochem.,?268?245 2) Graham?et al.?(1987),?Inhibition of the mammalian beta-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-acylamino-3-substituted propenoic acids; J. Med. Chem.,?30?1074 3) Keynan?et al. (1995),?The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA; Antimicreob. Agents Chemother.,?39?1629 4) Park?et al.?(2016),?Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer; Oncotarget,?7?9501
Cilastatin sodium Preparation Products And Raw materials
Tag:Cilastatin sodium(81129-83-1) Related Product Information
Sodium benzoate Cilastatin Sodium chloride Sodium acetate N,N-Dimethylformamide Ethylbenzene Ethylparaben CHLOROETHANE Sodium carbonate Ethyl acetate Hydrogen Sodium bicarbonate Diclofenac sodium Sodium formate Ethanol Ethyl acrylate Ethyl cellulose Sodium hydroxide