ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Mitogen-activated protein kinase (MAPK) >JNK inhibitors >JNK-IN-8

JNK-IN-8

JNK-IN-8 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: CAS:1410880-22-6
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: Biochempartner
Tel: 0086-13720134139
Email: candy@biochempartner.com
Products Intro: Product Name:JNK-IN-8
CAS:1410880-22-6
Purity:98% HPLC LCMS Package:10G;20G
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Email: linda@hubeijusheng.com
Products Intro: Product Name:JNK-IN-8
CAS:1410880-22-6
Purity:0.99 Package:5KG;1KG
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:JNK-IN-8
CAS:1410880-22-6
Purity:>98% Package:20mg Remarks:BOC Sciences also provides custom synthesis services for JNK-IN-8.
Company Name: career henan chemical co
Tel: +86-0371-86658258 15093356674;
Email: factory@coreychem.com
Products Intro: Product Name:JNK-IN-8
CAS:1410880-22-6
Purity:99% Package:1KG;USD

JNK-IN-8 manufacturers

  • JNK-IN-8
  • JNK-IN-8 pictures
  • $0.00 / 1KG
  • 2019-12-20
  • CAS:1410880-22-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: kg/T
JNK-IN-8 Basic information
Product Name:JNK-IN-8
Synonyms:JNK-IN-8;(E)-3-(4-(diMethylaMino)but-2-enaMido)-N-(3-Methyl-4-(4-(pyridin-3-yl)pyriMidin-2-ylaMino)phenyl)benzaMide;3-[[4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide;JNK Inhibitor XVI;Benzamide, 3-[[4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-;3-[[4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide JNK-IN-8;JNK-IN-8 Only for R&D;JNK-IN-8 USP/EP/BP
CAS:1410880-22-6
MF:C29H29N7O2
MW:507.59
EINECS:
Product Categories:Inhibitors;MAPK
Mol File:1410880-22-6.mol
JNK-IN-8 Structure
JNK-IN-8 Chemical Properties
density 1.283±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility ≥25.4 mg/mL in DMSO; insoluble in H2O; ≥9.24 mg/mL in EtOH with gentle warming and ultrasonic
pka13.34±0.70(Predicted)
form powder
color white to beige
Safety Information
HS Code 2933599590
MSDS Information
JNK-IN-8 Usage And Synthesis
UsesJNK-IN-8 has been used as an inhibitor to address the importance of JNK signaling in withaferin A (WFA)-induced apoptosis of myelodysplastic syndromes (MDS)-L cells.
DefinitionChEBI: 3-[[4-(dimethylamino)-1-oxobut-2-enyl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide is a member of benzamides.
Biological Activityjnk-in-8 is a specific jnk1/2/3 inhibitor with ic50 value of 4.67, 18.7, 0.98 nm respectively [1].c-jun n-terminal kinase (jnk) 1, 2 and 3 belong to the mitogen-activated protein kinase (mapk) family, which are able to phosphorylate c-jun on the ser63 and ser73 residue.they are responsive for stress stimuli, including cytokines and heat shock, and get involved in t cell differentiation and cell apoptosis process. jnk 1 and 2 are ubiquitous in all cell types but jnk 3 is only found in cells of brain, heart and testes tissues.jnk-in-8 is a jnk1/2/3 inhibitor with high specificity. when jnk-in-8 was profiled with a panel of 400 kinases, it exhibited specific binding to jnk 1/2/3 but not to other kinases. crystallization study also found that jnk-in-8 forms covalent bonds with conserved cysteine residue of jnk 1/2/3, resulting in a conformational change of the activation loop that blocks the substrate binding, thereby inhibiting the activity of jnk 1/2/3 [1].in hela cells and a375 cells, pretreatment of cells with jnk-in-8 resulted in the inhibition of c-jun which is a direct phosphorylation substrate of jnk 1/2/3, confirming the inhibitory action of jnk-in-8 on jnk 1/2/3. in hek293-ilr1 cells following stimulation by anisomycin, the jnk-in-8 was observed to inhibit c-jun but not msk1 and p38, and the inhibition was not reversible by removing jnk-in-8 from culture medium. additionally, jnk-in-8 only exhibited on-pathway inhibition of jnk signaling pathway, which can be monitored by the phosphorylation of c-jun [1].
Biochem/physiol ActionsJNK-IN-8 is a potent, selective and irreversible inhibitor of JNK1/2/3 that inhibits phosphorylation of c-Jun. JNK-IN-8 forms covalent bonds with a conserved cysteine residue.
targetJNK1
references[1]. zhang t et al., discovery of potent and selective covalent inhibitors of jnk. chemical biology. 2012, 19(1):140-154.
JNK-IN-8 Preparation Products And Raw materials
Tag:JNK-IN-8(1410880-22-6) Related Product Information
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