L-778123 manufacturers
- L-778123 free base
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- $287.00 / 5mg
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2025-08-21
- CAS:183499-57-2
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | L-778123 Basic information |
| Product Name: | L-778123 | | Synonyms: | 4-[[5-[[4-(3-chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]Benzonitrile;Benzonitrile, 4-[[5-[[4-(3-chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]-;4-[5-[4-(3-Chlorophenyl)-3-oxopiperazin-1-ylmethyl]imidazol-1-ylmethyl]benzonitrile;4-((5-((4-(3-Chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile;123;L 778;L-778;L-778123 free base | | CAS: | 183499-57-2 | | MF: | C22H20ClN5O | | MW: | 405.88 | | EINECS: | | | Product Categories: | | | Mol File: | 183499-57-2.mol |  |
| | L-778123 Chemical Properties |
| Boiling point | 698.9±55.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml,Ethanol: 10 mg/ml | | form | A crystalline solid | | pka | 7.07±0.20(Predicted) | | color | White to off-white |
| | L-778123 Usage And Synthesis |
| Uses | L-778123 is a dual FPTase and GGPTase-I inhibitor, with IC50s of 2 nM and 98 nM respectively[1][2]. | | Definition | ChEBI: L-778,123 (free base) is a member of the class of imidazoles that is 1H-imidazole substituted by (4-cyanophenyl)methyl and [4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl groups at positions 1 and 5, respectively. It is a dual inhibitor of FPTase and GGPTase-I. It has a role as an EC 2.5.1.58 (protein farnesyltransferase) inhibitor, an EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor and an antineoplastic agent. It is a member of monochlorobenzenes, a piperazinone, a member of imidazoles, a tertiary amino compound and a nitrile. | | in vivo | L-778123 (50 mg/kg/day, infusion, 7 days) inhibits both HDJ2 and Rap1A prenylation in PBMCs of dogs, but without inhibition in Ki-Ras prenylation[1]. | | References | [1] Lobell RB, et al. Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I. Mol Cancer Ther. 2002 Jul;1(9):747-758. PMID:12479371
[2] Ghasemi S, et al. Comparison of Cytotoxic Activity of L778123 as a Farnesyltranferase Inhibitor and Doxorubicin against A549 and HT-29 Cell Lines. Adv Pharm Bull. 2013;3(1):73-77. DOI:10.5681/apb.2013.012
[3] Fredrick O. Onono, et al. The Farnesyltransferase Inhibitor (FTI) L-778,123 Displays Promising Anti-Leukemia Activity. Blood (2008); 112 (11): 2627.
[4] Si MS, et al. Inhibition of lymphocyte activation and function by the prenylation inhibitor L-778,123. Invest New Drugs. 2005 Jan;23(1):21-9. DOI:10.1023/B:DRUG.0000047102.26698.08 |
| | L-778123 Preparation Products And Raw materials |
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