- PSI 7851
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- $3.00 / 3KG
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2019-08-07
- CAS:1064684-44-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100kg
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| | PSI 7851 Basic information |
| Product Name: | PSI 7851 | | Synonyms: | PSI 7851;N-[(2'R)-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester;PSI-7977, SOFOSBUVIR;CS-1996;L-Alanine, N-[(2'R)-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl ester;GS 9851;GS9851;GS-9851 | | CAS: | 1064684-44-1 | | MF: | C22H29FN3O9P | | MW: | 529.45 | | EINECS: | | | Product Categories: | | | Mol File: | 1064684-44-1.mol |  |
| | PSI 7851 Chemical Properties |
| density | 1.41±0.1 g/cm3(Predicted) | | pka | 9.39±0.10(Predicted) |
| | PSI 7851 Usage And Synthesis |
| Uses | GS-9851 (PSI-7851) is an HCV nonstructural protein 5B (NS5B) inhibitor with potential activity for the treatment of HCV infection. GS-9851 showed good tolerability in patients with initial HCV genotype 1 infection. GS-9851 is rapidly cleared from the body with a half-life of approximately 1 hour. The maximum concentration of GS-9851 and the increase in the area under the compound concentration-time curve were not dose-proportional, especially at the highest dose[1]. | | References | [1] Pharmacokinetics, pharmacodynamics, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor, following multiple ascending doses in patients with chronic hepatitis C infection
[2] Discovery of a β-D-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus
J. Med. Chem., Article ASAP
DOI: 10.1021/jm100863x
Publication Date (Web): September 16, 2010 |
| | PSI 7851 Preparation Products And Raw materials |
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