| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:LUF 6283
CAS:92933-48-7
Purity:98% by HPLC Remarks:LUF 6283 is a partial hydroxycarboxylic acid receptor 2 agonist. It can effectively lower plasma lipid levels.
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| | 5-Butyl-1H-pyrazole-3-carboxylic acid Basic information |
| | 5-Butyl-1H-pyrazole-3-carboxylic acid Chemical Properties |
| Melting point | 166-167 °C | | Boiling point | 385.8±30.0 °C(Predicted) | | density | 1?+-.0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO: soluble10mg/mL (clear solution; warmed) | | form | powder | | pka | 15.44±0.10(Predicted) | | color | white to beige |
| | 5-Butyl-1H-pyrazole-3-carboxylic acid Usage And Synthesis |
| Description | LUF6283 is a partial agonist of GPR109A/HCA2 G protein-coupled receptors (Ki = 0.55 μM in a radioligand binding assay). It stimulates [35S]-GTPγS binding and increases phosphorylation of ERK in HEK293T cells expressing GPR109A/HCA2 receptors (EC50s = 3.1 and 0.32 μM, respectively). In vivo, LUF6283 (400 mg/kg per day) reduces plasma levels of VLDL and hepatic expression of apolipoprotein B in mice. | | Uses | LUF 6283 is a partial agonist of HCA2 and is a promising drug candidate to achieve a beneficial lipid lowering effect of niacin, ultimately treating dyslipidemic disorders. |
| | 5-Butyl-1H-pyrazole-3-carboxylic acid Preparation Products And Raw materials |
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