- ZLN-005
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- $1.00 / 1ASSAYS
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2019-09-05
- CAS:49671-76-3
- Min. Order: 1ASSAYS
- Purity: 96%
- Supply Ability: 10kg
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| Product Name: | ZLN005 | | Synonyms: | 2-(4-TERT-BUTYLPHENYL)-1H-BENZO[D]IMIDAZOLE;2-(4-tert-Butylphenyl)-1H-benzimidazole;2-(4-tert-Butylphenyl)benzimidazole;ZLN005, >=98%;2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazole;2-(4-tert-Butylphenyl)benzimidazole ZLN005;ZLN005 2-(4-tert-Butylphenyl)benzimidazole;ZLN005 | | CAS: | 49671-76-3 | | MF: | C17H18N2 | | MW: | 250.34 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 49671-76-3.mol |  |
| | ZLN005 Chemical Properties |
| Melting point | 257-258℃ | | Boiling point | 415.3±38.0 °C(Predicted) | | density | 1.102±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | DMSO: soluble10mg/mL, clear | | pka | 11.52±0.10(Predicted) | | form | powder | | color | white to beige |
| Hazard Codes | Xn | | Risk Statements | 22-36 | | Safety Statements | 26 | | WGK Germany | 3 |
| | ZLN005 Usage And Synthesis |
| Description | Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a tissue-specific and inducible transcriptional coactivator for several nuclear receptors and plays a key role in energy metabolism, hepatic gluconeogenesis, and cholesterol homoeostasis. ZLN005 is a small molecule that stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM. Chronic administration of 15 mg/kg/day ZLN005 to diabetic db/db mice increased PGC-1α and downstream gene transcription in skeletal muscle, increasing fat oxidation and improving glucose tolerance, pyruvate tolerance, and insulin sensitivity. | | Uses | ZLN005 increaces PGC-1α and downstream gene transcription in skeletal muscles and increases fat oxidation and improved the glucose tolerance, pyruvate tolerance, and insulin sensitivity of diabetic db/db mice. |
| | ZLN005 Preparation Products And Raw materials |
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