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| Product Name: | FLI-06 | | Synonyms: | FLI-06;1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester;1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester FLI-06;3-QUINOLINECARBOXYLIC ACID, 1,4,5,6,7,8-HEXAHYDRO-2,7,7-TRIMETHYL-4-(4-NITROPHENYL)-5-OXO-, CYCLOHEXYL ESTER;FLI-06, 98%, a notch signaling and the early secretory pathway inhibitor;FLI-06 |FLI06;Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate;CS-1434 | | CAS: | 313967-18-9 | | MF: | C25H30N2O5 | | MW: | 438.52 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 313967-18-9.mol |  |
| | FLI-06 Chemical Properties |
| Melting point | 199-202oC | | Boiling point | 597.5±50.0 °C(Predicted) | | density | 1.25±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble5mg/mL, clear (warmed) | | form | powder | | pka | 0.78±0.70(Predicted) | | color | white to beige | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week. |
| RIDADR | 3077 | | WGK Germany | 3 | | HS Code | 29339900 |
| | FLI-06 Usage And Synthesis |
| Description | FLI-06 (313967-18-9) was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It was found to disrupt the Golgi apparatus in a manner distinct from that of brefeldin A. It inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER. Thus FLI-06 is the first small molecule acting at such an early stage in secretory traffic.1 | | Uses | FLI-06 is a novel inhibitor of Notch signalling and the early secretory pathway. | | References | 1) Kramer?et al., (2013),?Small molecules intercept Notch signaling and the early secretory pathway; Nat. Chem. Biol.?9 731 |
| | FLI-06 Preparation Products And Raw materials |
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