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| Product Name: | (S)-(R)-JOSIPHOS | | Synonyms: | (S)-(+)-1-[(R)-2-(Diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine ethanol adduct,97% (S)-(R)-JOSIPHOS;(S)-(+)-1-[(R)-2-(Diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine ethanol adduct (S)-(R)-JOSIPHOS;(S)-1-[(RP)-2-(Diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine >=97%;(2S)-1-[(1S)-1-(Dicyclohexylphosphino)ethyl]-2-(diphenylphosphino)ferrocene;JOSIPHOS SL-J001-2;(S)-(+)-1-[(R)-2-(DIPHENYLPHOSPHINO)FERROCENYL]ETHYLDICYCLOHEXYLPHOSPHINE;(S)-1-[(1R)-2-(DIPHENYLPHOSPHINO)FERROCENYL]ETHYLDICYCLOHEXYLPHOSPHINE;(S)-(+)-1-[(R)-2-(Diphenylphospino)ferrocenyl] ethylbicyclohexylphosphine | | CAS: | 162291-02-3 | | MF: | C36H44FeP210* | | MW: | 594.53 | | EINECS: | | | Product Categories: | Chiral Phosphine;Ferrocene Series;Josiphos Series;organophosphine ligand | | Mol File: | 162291-02-3.mol |  |
| | (S)-(R)-JOSIPHOS Chemical Properties |
| alpha | +360° (c 0.5, CHCl3) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | Powder | | color | orange | | Stability: | store cold |
| | (S)-(R)-JOSIPHOS Usage And Synthesis |
| Reactions |
- Ferrocenylphosphine ligands of the type cpFecp(PR2)(*CH(CH3)PR'2) are a class of asymmetric ligands developed at Solvias in Basel, Switzerland. Ligands of this type are currently used industrially in the stereoselective synthesis of commercial products. A unique feature of these bidentate ligands is the presence of a fixed phosphine moiety and a stereogenic,functionalized side chain, which can be easily modified to accommodate electronic and steric requirements. Based on a versatile synthetic procedure starting with optically active ferrocenes of the type cpFecp(PR2)(*CH(CH3)X) [X = OAc or NR2], a variety of donor atoms can be introduced into the side chain.4 These ferrocene based phosphine ligands have wide application in the stereoselective hydrogenation of substituted acetamidoacrylates, enol acetates, β-ketoesters and simple alkenes.
- Pd-catalyzed, enantioselective, intramolecular α-substituted cyclic ketones: facile synthesis of functionalized chiral spirobicycles.
- Asymmetric boron conjugate addition of α,β-unsaturated carbonyl compounds catalyzed by
- CuOTf/Josiphos under non-alkaline conditions.
- Chiral amides via copper-catalyzed enantioselective conjugate addition.
- Ruthenium-catalyzed enantioselective synthesis of β-amino alcohols from 1,2-diols by “borrowing hydrogen”.
- Cobalt-catalyzed asymmetric addition of silylacetylenes to 1,1-disubstituted allenes.
| | Chemical Properties | Dark orange powder | | General Description | sold in collaboration with Solvias AG |
| | (S)-(R)-JOSIPHOS Preparation Products And Raw materials |
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