| Company Name: |
DKMbiochem.Co. Ltd
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| Tel: |
15901859516 |
| Email: |
sales@DKMbiochem.com |
| Products Intro: |
Product Name:3-broMo-10-(difluoroMethyl)-9H-benzo[f]iMidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine
Purity:98% Package:1g,5g Remarks:Ro4938581
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| Company Name: |
Shanghai Biopharmaleader Co., Ltd.
|
| Tel: |
+86 18721201413 |
| Email: |
sales@biopharmaleader.com |
| Products Intro: |
Product Name:RO4938581
CAS:883093-10-5
Purity:98%HPLC Package:10g,100g
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3-broMo-10-(difluoroMethyl)-9H-benzo[f]iMidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine manufacturers
- RO 4938581
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- $1230.00 / 25mg
-
2024-10-28
- CAS:883093-10-5
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 3-broMo-10-(difluoroMethyl)-9H-benzo[f]iMidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine Basic information |
| Product Name: | 3-broMo-10-(difluoroMethyl)-9H-benzo[f]iMidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine | | Synonyms: | 3-broMo-10-(difluoroMethyl)-9H-benzo[f]iMidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine;RO4938581;9H-Imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine, 3-bromo-10-(difluoromethyl)- | | CAS: | 883093-10-5 | | MF: | C13H8BrF2N5 | | MW: | 352.14 | | EINECS: | | | Product Categories: | | | Mol File: | 883093-10-5.mol | ![3-broMo-10-(difluoroMethyl)-9H-benzo[f]iMidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine Structure](CAS/20150408/GIF/CB82716620.gif) |
| | 3-broMo-10-(difluoroMethyl)-9H-benzo[f]iMidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine Chemical Properties |
| Boiling point | 559.8±60.0 °C(Predicted) | | density | 1.93±0.1 g/cm3(Predicted) | | pka | 1.62±0.20(Predicted) | | form | Solid | | color | White to off-white |
| | 3-broMo-10-(difluoroMethyl)-9H-benzo[f]iMidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine Usage And Synthesis |
| Uses | RO 4938581 is a potent and selective GABAA α5 inverse agonist, with a Ki of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfunction. | | in vivo | RO 4938581 (0.3-1 mg/kg, p.o.) reverses a working memory impairment induced by scopolamine the delayed match to position (DMTP) task and a spatial learning impairment induced by diazepam (RO 4938581; 1-10 mg/kg, po)[1]. | | References | [1] Knust H, et al. The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5940-4. DOI:10.1016/j.bmcl.2009.08.053 |
| | 3-broMo-10-(difluoroMethyl)-9H-benzo[f]iMidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine Preparation Products And Raw materials |
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