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TH287

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TH287 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:TH287
CAS:1609960-30-6
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: career henan chemical co
Tel: +86-0371-86658258
Email: sales@coreychem.com
Products Intro: Product Name: TH287
CAS:1609960-30-6
Purity:95%~99% Package:1KG;1USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:TH287；TH287 hydrochloride
CAS:1609960-30-6
Purity:99.50% Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:TH-287
CAS:1609960-30-6
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:TH287
CAS:1609960-30-6
Purity:99% Package:5KG;1KG Remarks:TH287

TH287 manufacturers

  • TH287
  • TH287 pictures
  • $1.00 / 1KG
  • 2019-09-06
  • CAS:1609960-30-6
  • Min. Order: 1KG
  • Purity: 95%~99%
  • Supply Ability: per week:100kg
TH287 Basic information
Product Name:TH287
Synonyms:TH287 hydrochloride;TH287;6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine;6-(2,3-Dichlorophenyl)-N4-methylpyrimidine-2,4-diamine hydrochloride;6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine;TH287;TH-287;CS-1671;TH287, >98%
CAS:1609960-30-6
MF:C11H10Cl2N4
MW:269.13
EINECS:
Product Categories:Inhibitors
Mol File:1609960-30-6.mol
TH287 Structure
TH287 Chemical Properties
Boiling point 512.2±60.0 °C(Predicted)
density 1.440±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble5mg/mL, clear (warmed)
pka5.91±0.10(Predicted)
form powder
color white to beige
Safety Information
Hazard Codes Xn
Risk Statements 22-41
Safety Statements 26-39
WGK Germany 3
MSDS Information
TH287 Usage And Synthesis
DescriptionHuman mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH287 is an MTH1 inhibitor (IC50 = 0.8 nM) that selectively kills cancer cell lines (IC50s = 0.8-3.06 μM) without significant cytotoxicity towards primary or immortalized cells (IC50s = ≥20 μM). At up to 100 μM it does not show significant effect towards the related nudix hydrolase protein family members MTH2, NUDT5, NUDT12, NUDT14, and NUDT16, as well as other proteins with known nucleoside triphosphate pyrophosphatase activity (dCTPase, dUTPase, and ITPA).
Uses6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine is known to possess antitumor effects and nanomolar MTH1-inhibitory activity in vitro for cancer cell survival.
references1. gad h, koolmeister t, jemth as et al. mth1 inhibition eradicates cancer by preventing sanitation of the dntp pool. nature. 2014 apr 10;508(7495):215-21.
TH287 Preparation Products And Raw materials
Raw materials2,3-Dichlorophenylboronic acid-->NSC36831-->4-chloro-6-(2,3-dichlorophenyl)pyrimidin-2-amine-->Methylamine
Tag:TH287(1609960-30-6) Related Product Information
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