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Naproxen

Naproxen Suppliers list
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd.
Tel: +86-10-60279497 +86(0)15646567669
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:Naproxen
CAS:22204-53-1
Purity:98%99% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Shanghai Bojing Chemical Co.,Ltd.
Tel: +86-21-37122233
Email: Candy@bj-chem.com
Products Intro: Product Name:Naproxen
CAS:22204-53-1
Purity:99% Package:1Kg;25kg/ Drum or as customer request
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:22204-53-1
CAS:22204-53-1
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: PI & PI BIOTECH INC.
Tel: 020-81716320
Email: Sales@pipitech.com
Products Intro: Product Name:Naproxen
CAS:22204-53-1
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:(2S)-2-(6-Methoxynaphthalen-2-yl)propanoic acid
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 86-0551-65418684 18949823763
Email: info@tnjchem.com
Products Intro: Product Name:Naproxen
CAS:22204-53-1
Purity:99.9% USP BP EP Package:1KG;5USD

Lastest Price from Naproxen manufacturers

  • Naproxen
  • US $20.00 / 公斤/桶
  • 2019-10-29
  • CAS:22204-53-1
  • Min. Order: 1公斤/桶
  • Purity: 99%
  • Supply Ability: EX:20ton
  • Naproxen、INN
  • US $83.00 / KG
  • 2019-10-23
  • CAS:22204-53-1
  • Min. Order: 10g
  • Purity: 99%
  • Supply Ability: 20tons
  • Naproxen
  • US $1.00 / KG
  • 2019-07-06
  • CAS:22204-53-1
  • Min. Order: 1G
  • Purity: 98%
  • Supply Ability: 100KG
Naproxen Basic information
Non-steroidal anti-inflammatory drugs Chemical Properties Uses Used in Particular Diseases production method Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage Characteristics Extinguishing agent
Product Name:Naproxen
Synonyms:()-2-(methoxy-2-naphthyl)-propionicacid;()-2-(methoxy-2-naphthyl)-propionsaeure;()-propionicaci;(+)-2-(Methoxy-2-naphthyl)-propionic acid;(+)-2-(methoxy-2-naphthyl)-propionicacid;(+)-2-(Methoxy-2-naphthyl)-propionsaeure;(+)-2-naphthaleneaceticaci;(+)-6-Methoxy-alpha-methyl-2-napthaleneacetic acid
CAS:22204-53-1
MF:C14H14O3
MW:230.26
EINECS:244-838-7
Product Categories:chiral;Carboxylic Acids (Chiral);Chiral Building Blocks;for Resolution of Bases;Optical Resolution;Synthetic Organic Chemistry;Intermediates & Fine Chemicals;Pharmaceuticals;Lipid signaling;Aromatics;ALEVE;Other APIs
Mol File:22204-53-1.mol
Naproxen Structure
Naproxen Chemical Properties
Melting point 152-154 °C(lit.)
alpha D +66° (in chloroform)
Boiling point 332.25°C (rough estimate)
density 1.1450 (rough estimate)
refractive index 67.5 ° (C=1, CHCl3)
Fp 9℃
storage temp. -20°C Freezer
solubility Practically insoluble in water, soluble in ethanol (96 per cent) and in methanol.
pkapKa 4.28± 0.02(H2O,t =25,I=0.01) (Uncertain)
form powder
optical activity[α]25/D +66°, c = 1 in chloroform
Water Solubility Insoluble in water.
Merck 14,6417
BRN 3591067
CAS DataBase Reference22204-53-1(CAS DataBase Reference)
NIST Chemistry ReferenceNaproxen(22204-53-1)
EPA Substance Registry System2-Naphthaleneacetic acid, 6-methoxy-.alpha.-methyl-, (.alpha.S)- (22204-53-1)
Safety Information
Hazard Codes Xn,T,F
Risk Statements 22-39/23/24/25-23/24/25-11-36/37/38
Safety Statements 36/37-45-16-7-26
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS UF5275000
HazardClass 6.1(b)
PackingGroup III
HS Code 29189900
Hazardous Substances Data22204-53-1(Hazardous Substances Data)
ToxicityLD50 in mice (mg/kg): 435 i.v.; 1234 orally; in rats (mg/kg): 575 i.p.; 534 orally (Roszkowski)
MSDS Information
ProviderLanguage
(+)-2-(6-Methoxy-2-naphthyl)-propionic acid English
SigmaAldrich English
ALFA English
Naproxen Usage And Synthesis
Non-steroidal anti-inflammatory drugsNaproxen is a non-steroidal anti-inflammatory drug ,it is a PG synthase inhibitor, which can inhibit prostaglandin synthetase, it has significant analgesic and antipyretic effects, oral absorption is rapid and complete, 2 to 4 hours after a dose ,plasma concentration reaches the peak, in the blood , more than 99% is bound to plasma proteins, t1/2 is 13 to 14 hours, about 95% is discharged from the urine with the prototype and metabolites.it is clinically used For the treatment of rheumatic and rheumatoid arthritis , osteoarthritis, ankylosing spondylitis, gout, arthritis, tenosynovitis.it can also be used to alleviate pain caused by musculoskeletal sprains, contusions,damages and dysmenorrhea . But it should be noted that like other non-steroidal anti-inflammatory drugs, the same serious gastrointestinal adverse reactions could occur at any time while taking naproxen during treatment, so the active gastroduodenal ulcer patients are hanged, other gastrointestinal tract disease patients should take this drug under close medical supervision.
The above information is edited by the Chemicalbook of Tian Ye.
Chemical PropertiesWhite crystal or crystalline powder. Melting point 155.3 ℃. Soluble in acetone, soluble in methanol, ethanol, acetic acid, insoluble in benzene, practically insoluble in water. In case of light,it is color-graded, odorless, tasteless.
UsesIt is a non-steroidal anti-inflammatory drug for the relief of fever and inflammation and pain associated with arthritis or other symptoms , it has anti-inflammatory, antipyretic and analgesic effects. Naproxen plays a role by inhibiting the cyclooxygenase, which generates prostaglandin and is one kind of enzymes related to inflammatory mediators . It is recommended to take the drug during meals to reduce stomach irritation.
Used in Particular DiseasesAcute Gouty Arthritis:
Dosage and Frequency: 500 mg twice daily for 3 days, then 250–500 mg daily for 4–7 days
production methodby methylation, acetylation With 2-naphthol , 6-methoxy-2-acetonaphthone is produced, then it is condensed with acid ester, then generate the product through isomerization, hydrolysis, oxidation, and split and other reactions.
CategoryToxic substances
Toxicity gradingHighly toxic
Acute toxicityOral-rat LD50 248 mg/kg; Oral-Mouse LD50: 360 mg/kg
Flammability and hazard characteristicsCombustible; combustion produces toxic and acrid smoke.
Storage CharacteristicsVentilated, low-temperature ,dry storeroom, it should be stored and transported from food raw materials separately.
Extinguishing agentWater, dry powder, foam,sand
Chemical Propertieswhite to light yellow crystal powde
UsesAn anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory
IndicationsNaproxen (Naprosyn) also has pharmacological properties and clinical uses similar to those of ibuprofen. It exhibits approximately equal selectivity for COX-1 and COX-2 and is better tolerated than certain NSAIDs, such as indomethacin. Adverse reactions related to the GI tract occur in about 14% of all patients, and severe GI bleeding has been reported. CNS complaints (headache, dizziness, drowsiness), dermatological effects (pruritus, skin eruptions, echinoses), tinnitus, edema, and dyspnea also occur.
DefinitionChEBI: A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such a osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes.
Brand nameNaprosyn (Roche).
General DescriptionNaproxen (Naprosyn, Anaprox), marketed as the (S)-enantiomer,is well absorbed after oral administration, givingpeak plasma levels in 2 to 4 hours and a half-life of 13 hours.Naproxen is highly protein bound and displaces most protein-bound drugs. It is recommended for use in RA, OA, acute gouty inflammation, and in primary dysmenorrhea. Itshows good analgesic activity (i.e., 400 mg is comparable to75–150 mg of oral meperidine and superior to 65 mg ofpropoxyphene and 325 mg of aspirin plus 30 mg of codeine).It is also available OTC as 200-mg tablets (Aleve).
Veterinary Drugs and TreatmentsThe manufacturer lists the following indications: “…for the relief of inflammation and associated pain and lameness exhibited with myositis and other soft tissue diseases of the musculoskeletal system of the horse.” (Package Insert; Equiproxen?—Syntex). It has also been used as an antiinflammatory/analgesic in dogs for the treatment of osteoarthritis and other musculoskeletal inflammatory diseases (see adverse reactions below).
Naproxen Preparation Products And Raw materials
Raw materialsMethanol-->Toluene-->Hydrogen-->2-Naphthol-->2-Acetyl-6-methoxynaphthalene
Preparation ProductsNaproxen sodium
Tag:Naproxen(22204-53-1) Related Product Information
(S)-Naproxen Acyl-b-D-glucuronide Benzyl Ester 4-(NITROOXY)BUTYL (2S)-2-(6-METHOXY-2-NAPHTHYL)PROPANOATE (2R)-2-AMINO-2-(6-METHOXY(2-NAPHTHYL))PROPANOIC ACID NAPROXEN, [O-METHYL-14C] Naproxen Thiophanate-methyl Methoxy Methyl Methyl bromide p-Anisidine 2-Naphthylacetic acid Kresoxim-methyl Methylparaben Anisic acid p-Anisaldehyde Methyl acrylate α-Lipoic Acid Bensulfuron methyl