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| | CYCLO(-HIS-PRO) Basic information |
| Product Name: | CYCLO(-HIS-PRO) | | Synonyms: | (3S,6S)-3-(3H-imidazol-4-ylmethyl)-1,4-diazabicyclo[4.4.0]decane-2,5-dione;Histidylproline diketopiperazine;histidylproline dioxopiperazine;Cyclo-Pro-His-HO;HIS-PRO, CYCLIC;CYCLO(-HIS-PRO);Cyclo(histidyl-proline);CYCLO(HISTIDYL-PROLINE); HISTIDYLPROLINE DIKETOPIPERAZINE | | CAS: | 53109-32-3 | | MF: | C11H14N4O2 | | MW: | 234.25 | | EINECS: | | | Product Categories: | | | Mol File: | 53109-32-3.mol |  |
| | CYCLO(-HIS-PRO) Chemical Properties |
| Melting point | 162-164 °C | | Boiling point | 659.3±48.0 °C(Predicted) | | density | 1.41±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 1 mg/ml | | form | A neat oil | | pka | 12.73±0.40(Predicted) |
| | CYCLO(-HIS-PRO) Usage And Synthesis |
| Uses | Cyclo(L-histidyl-L-proline) is used in the pharmaceutical composition comprising cyclo(His-Pro) for preventing or treating obesity. | | Definition | ChEBI: Cyclo(L-His-L-Pro) is a homodetic cyclic peptide resulting from the formal condensation of both the amino and acid groups of L-histidine with the acid and amino groups of L-proline. It is a metabolite of thyrotropin-releasing hormone (TRH). It has a role as a human blood serum metabolite, a dopamine uptake inhibitor and an anti-inflammatory agent. It is a homodetic cyclic peptide, a dipeptide, a pyrrolopyrazine and a member of imidazoles. It is functionally related to a L-histidine and a L-proline. |
| | CYCLO(-HIS-PRO) Preparation Products And Raw materials |
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