- Mirin
-
- $0.00 / 25kg
-
2024-04-12
- CAS:1198097-97-0
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 2000ton
|
| Product Name: | Mirin | | Synonyms: | (5Z)-2-Amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone;CS-2593;4(5H)-Thiazolone, 2-amino-5-[(4-hydroxyphenyl)methylene]-, (5Z)-;(Z)-2-Amino-5-(4-hydroxybenzylidene)thiazol-4(5H)-one;(Z)-Mirin;(Z)-Mirin,Inhibitor,(Z)Mirin,(Z) Mirin,inhibit;(5Z) -2-amino-5- [(4-hydroxyphenyl) methylene] -4 (5H) - thiazolidone | | CAS: | 1198097-97-0 | | MF: | C10H8N2O2S | | MW: | 220.25 | | EINECS: | | | Product Categories: | | | Mol File: | 1198097-97-0.mol |  |
| | Mirin Chemical Properties |
| Boiling point | 441.6±55.0 °C(Predicted) | | density | 1.49±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | insoluble in EtOH; insoluble in H2O; ≥9.3 mg/mL in DMSO | | form | solid | | pka | 8.70±0.30(Predicted) |
| | Mirin Usage And Synthesis |
| Uses | Mirin is an MRN-ATM pathway inhibitor blocking 3’ and 5’ exonuclease activity associated with Mre11, inducing G2 cell cycle arrest. | | Biological Activity | mirin is a potent mrn complex inhibitor. mirin inhibits mre11-associated exonuclease activity, rather than alters dna-binding or mrn complex formation. moreover, mirin prevents mrn-dependent activation of atm in response to dna double-strand breaks, with an ic50 value of 12 μm. the mrn complex acts as a dna damage sensor, responsible for maintaining genome stability during dna replication, promoting homology-dependent dna repair and activating atm. the mrn-atm pathway plays an essential role in sensing and signaling from dna double-strand breaks.1. dupré a, boyer-chatenet l, sattler rm, et al. a forward chemical genetic screen reveals an inhibitor of the mre11-rad50-nbs1 complex. nature chemical biology, 2008, 4(2): 119-125. | | storage | Store at +4°C |
| | Mirin Preparation Products And Raw materials |
|