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BOC Sciences
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1-631-485-4226; 16314854226 |
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| Products Intro: |
Product Name:PF 5006739
CAS:1293395-67-1
Purity:98% by HPLC Remarks:PF 5006739 is a potent inhibitor of casein kinases 1 delta (CK1δ) and 1 epsilon (CK1ε) (IC50 values are 3.9 and 17 nM, respectively). It mediates circadian rhythm phase-delaying effects in vivo.
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| | PF-5006739 Basic information |
| Product Name: | PF-5006739 | | Synonyms: | PF-5006739;PF-5006739 >=98% (HPLC);2-Pyrimidinamine, 4-[4-(4-fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-;PF 5006739;PF5006739;4-[4-(4-Fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-2-pyrimidinamine;4-[5-(4-fluorophenyl)-3-[1-(1,2-oxazol-3-ylmethyl)piperidin-4-yl]imidazol-4-yl]pyrimidin-2-amine | | CAS: | 1293395-67-1 | | MF: | C22H22FN7O | | MW: | 419.45 | | EINECS: | | | Product Categories: | | | Mol File: | 1293395-67-1.mol |  |
| | PF-5006739 Chemical Properties |
| storage temp. | room temp | | solubility | Soluble in DMSO | | form | powder | | color | white to beige |
| RIDADR | UN 2811 6.1 / PGIII |
| | PF-5006739 Usage And Synthesis |
| Biochem/physiol Actions | PF-5006739 is a potent inhibitor of casein kinases 1 delta (CK1δ) and 1 epsilon (CK1ε), key regulators of the suprachiasmatic nucleus (SCN) central clock and also linked to the development of drug addiction through PERIOD proteins (PER1–3) and dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) modulation. PF-5006739 has low nM in vitro potency for CK1δ/ε (IC50 values of 3.9 nM for CK1δ and 17.0 nM for CK1ε) and high kinome selectivity. PF-5006739 induced profound phase delays in circadian periodicity in both nocturnal and diurnal animal models and attenuated opioid drug-seeking behavior in a rodent operant reinstatement model. | | storage | Store at +4°C |
| | PF-5006739 Preparation Products And Raw materials |
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