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| | Methylamino-PEG1-acid Basic information |
| Product Name: | Methylamino-PEG1-acid | | Synonyms: | Methylamino-PEG1-acid;Methylamino-PEG1-acid HCl salt;Propanoic acid, 3-[2-(methylamino)ethoxy]-;Me-NH-PEG1-CH2CH2COOH | | CAS: | 1367918-21-5 | | MF: | C6H13NO3 | | MW: | 147.17 | | EINECS: | | | Product Categories: | | | Mol File: | 1367918-21-5.mol |  |
| | Methylamino-PEG1-acid Chemical Properties |
| Boiling point | 253.9±20.0 °C(Predicted) | | density | 1.071±0.06 g/cm3(Predicted) | | pka | 4.24±0.10(Predicted) |
| | Methylamino-PEG1-acid Usage And Synthesis |
| Description | Methylamino-PEG1-acid is a PEG linker containing a carboxylic acid with a methylamine group. The hydrophilic PEG spacer increases solubility in aqueous media. The methylamine group is reactive with carboxylic acids, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | | Uses | Methylamino-PEG1-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Methylamino-PEG1-acid Preparation Products And Raw materials |
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