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ABT-670 manufacturers
- ABT-670
-
- $2500.00
-
2026-05-11
- CAS:630119-43-6
- Purity:
- Supply Ability: 10g
- ABT-670
-
- $2500.00
-
2025-07-17
- CAS:630119-43-6
- Purity:
- Supply Ability: 10g
|
| | ABT-670 Basic information |
| Product Name: | ABT-670 | | Synonyms: | ABT-670;Benzamide, 3-methyl-N-[[4-(1-oxido-2-pyridinyl)-1-piperidinyl]methyl]-;ABT670,ABT 670;3-Methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-(2,4'-bipyridine)-1'-ylmethyl)benzamide | | CAS: | 630119-43-6 | | MF: | C19H23N3O2 | | MW: | 325.4 | | EINECS: | | | Product Categories: | | | Mol File: | 630119-43-6.mol |  |
| | ABT-670 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO |
| | ABT-670 Usage And Synthesis |
| Uses | ABT-670 is a selective, oral bioavailable agonist of dopamine D4 receptor, with EC50 of 89 nM, 160 nM, and 93 nM for human D4, ferret D4, and rat D4, respectively. | | in vivo | ABT-670 (0.1 μmol/kg) robustly induces a high (75%) incidence of erections in male rats. ABT-670 exhibits excellent oral bioavailability in rat, dog, and monkey (68%, 85%, and 91%, respectively) with comparable efficacy, safety, and tolerability[1]. | | IC 50 | D4 Receptor | | References | [1] Patel MV, et al. Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction. J Med Chem. 2006 Dec 14;49(25):7450-65. DOI:10.1021/jm060662k |
| | ABT-670 Preparation Products And Raw materials |
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