盐酸去甲维拉帕米
| 中文名称 | 盐酸去甲维拉帕米 |
|---|---|
| 中文同义词 | 盐酸去甲维拉帕米;盐酸去甲维拉帕米(N-去甲 盐酸维拉帕米);去甲维拉帕米;去甲维拉帕米盐酸盐;盐酸去甲维他帕米;N-去甲维拉帕米盐酸盐;维拉帕米杂质J (EP);维拉帕米杂质J |
| 英文名称 | NORVERAPAMIL HYDROCHLORIDE |
| 英文同义词 | NORVERAPAMIL HCL;NORVERAPAMIL HYDROCHLORIDE;(+/-)-VERAPAMIL, NOR-METHYL-, HYDROCHLORIDE;a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-a-(1-methylethyl)- benzeneacetonitril;n-nor-(±)-verapamil hydrochloride;α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)- benzeneacetonitrile;(+-)-VERAPAMIL HYDROCHLORIDE, NOR-METHYL (NORVERAPAMIL HYDROCH;a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile |
| CAS号 | 67812-42-4 |
| 分子式 | C26H37ClN2O4 |
| 分子量 | 477.04 |
| EINECS号 | |
| 相关类别 | 合成;医药原料药;维拉帕米杂质;Metabolites;Various Metabolites and Impurities |
| Mol文件 | 67812-42-4.mol |
| 结构式 |  |
盐酸去甲维拉帕米 性质
| 熔点 | softens at 50°C, 155-160°C dec. |
|---|---|
| 闪点 | 9℃ |
| 储存条件 | desiccated |
| 溶解度 | H2O: >10 mg/mL |
| 形态 | 固体 |
| 颜色 | 白色 |
| 稳定性 | 吸湿性 |
| EPA化学物质信息 | Benzeneacetonitrile, .alpha.-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-.alpha.-(1-methylethyl)-, hydrochloride (1:1) (67812-42-4) |
Calcium channel blocker
P-glycoprotein (P-gp) inhibitor
Norverapamil hydrochloride ((±)-Norverapamil hydrochloride) is similarly effective as verapamil at inhibiting isoniazid and rifampicin tolerance and killing of intracellular M. tuberculosis in the absence of other drugs. norverapamil, also inhibits macrophage-induced tolerance and achieves similar serum levels to verapamil.
Verapamil and its major metabolite norverapamil were identified to be both mechanism-based inhibitors and substrates of CYP3A and reported to have non-linear pharmacokinetics in clinic.
Norverapamil hydrochloride (9 mg/kg; p.o.), a major metabolite of verapamil, has terminal half-life, AUC and Cmax values of 9.4 hours, 260 ng▪h/ml, and 41.6 ng/mL, respectively.
| Animal Model: | Male Sprague-Dawley rats |
| Dosage: | 9 mg/kg (Pharmacokinetic Study) |
| Administration: | Oral administration |
| Result: | t 1/2 =9.4 hours; AUC=260 ng▪h/mL; C max =41.6 ng/mL. |
安全信息
| 危险品运输编号 | UN 2811 6.1/PG 3 |
|---|---|
| WGK Germany | 3 |
| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-100750 | 盐酸去甲维拉帕米 Norverapamil hydrochloride | 67812-42-4 | 2mg | 950元 |
| 2024/01/25 | HY-100750 | 盐酸去甲维拉帕米 Norverapamil hydrochloride | 67812-42-4 | 5mg | 1550元 |