217799-03-6
| 中文名称 | 217799-03-6 |
|---|---|
| 中文同义词 | 化合物 T11764 |
| 英文名称 | KP496 |
| 英文同义词 | KP496;Benzoic acid, 2-[[[4-[[(4-chlorophenyl)sulfonyl]amino]butyl][[3-[[4-(1-methylethyl)-2-thiazolyl]methoxy]phenyl]methyl]amino]sulfonyl]-;KP496,KP-496 |
| CAS号 | 217799-03-6 |
| 分子式 | C31H34ClN3O7S3 |
| 分子量 | 692.27 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 217799-03-6.mol |
| 结构式 |  |
217799-03-6 性质
| 沸点 | 847.9±75.0 °C(Predicted) |
|---|---|
| 密度 | 1.378±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 3.09±0.36(Predicted) |
|
LTD 4
|
TXA 2 Receptor
|
KP496 significantly inhibits acute (day 7) and chronic (day 21) lung inflammation. KP496 attenuates the number of lymphocytes on day 7 and those of macrophages, neutrophils, and eosinophils on days 7 and 21. KP496 and prednisolone significantly suppress the increase of hydroxyl-L-proline content in the lung. Compare to respective vehicle control group, the inhibition ratio of KP496 and prednisolone for increase of hydroxyl-L-proline content is about 74 and 63%, respectively. The KP496 (100 mg/head) group and prednisolone (10 mg/kg) group exhibit significant inhibition of numbers of infiltrating total cells, eosinophils, monocytes/macrophages, and lymphocytes compare with the control group. Infiltration of all types of cells except neutrophils is decreased in the KP496 (30m g/head) group, though not to significant extents.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-U00253 | KP496 | 1 mg | 4500元 | |
| 2024/01/25 | HY-U00253 | 217799-03-6 KP496 | 217799-03-6 | 5mg | 8500元 |