AMG176 manufacturers
- Tapotoclax
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- $479.00 / 1mg
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2025-12-05
- CAS:1883727-34-1
- Min. Order:
- Purity: 98.80%
- Supply Ability: 10g
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| Product Name: | AMG176 | | Synonyms: | AMG176;CS-2836;Spiro[5,7-etheno-1H,11H-cyclobut[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-2(3H),1'(2'H)-naphthalen]-8(9H)-one, 6'-chloro-3',4',12,13,16,16a,17,18,18a,19-decahydro-16-methoxy-11,12-dimethyl-, 10,10-dioxide, (1'S,11R,12S,14E,16S,16aR,18aR)-;Tapotoclax;Tapotoclax（ AMG-176）;AMG-176 (TAPOTOCLAX);(1S,11'R,12'S,16'S,16a'R,18a'R,E)-6-Chloro-16'-methoxy-11',12'-dimethyl-3,4,12',13',16',16a',17',18',18a',19'-decahydro-1'H,2H,3'H,11'H-spiro[naphthalene-1,2'-[5,7]ethenocyclobuta[i][1,4]oxazepino[3,4-f][1]thia[2,7]diazacyclohexadecin]-8'(9'H)-one 10',10'-dioxide | | CAS: | 1883727-34-1 | | MF: | C33H41ClN2O5S | | MW: | 613.21 | | EINECS: | | | Product Categories: | | | Mol File: | 1883727-34-1.mol |  |
| | AMG176 Chemical Properties |
| density | 1.32±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 4.05±0.70(Predicted) | | color | White to off-white | | InChIKey | JQNINBDKGLWYMU-GEAQBIRJSA-N | | SMILES | S1(=O)(=O)[C@H](C)[C@@H](C)CC=C[C@H](OC)[C@]2([H])CC[C@@]2([H])CN2C[C@]3(C4=C(C=C(Cl)C=C4)CCC3)COC3C=CC(=CC2=3)C(=O)N1 |t:8| |
| | AMG176 Usage And Synthesis |
| Uses | Tapotoclax (AMG-176) is a potent, selective and orally active MCL-1 inhibitor, with a Ki of 0.13 nM[1][2]. | | IC 50 | Mcl-1: 0.13 nM (Ki) | | References | [1] Caenepeel S, et al. AMG 176, a Selective MCL1 Inhibitor, is Effective in Hematological Cancer Models Alone and in Combination with Established Therapies. Cancer Discov. 2018 Sep 25. pii: CD-18-0387. DOI:10.1158/2159-8290.CD-18-0387
[2] Garner TP, et al. Progress in targeting the BCL-2 family of proteins. Curr Opin Chem Biol. 2017 Aug;39:133-142. DOI:10.1016/j.cbpa.2017.06.014 |
| | AMG176 Preparation Products And Raw materials |
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