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| | Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Basic information |
| Product Name: | Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE | | Synonyms: | N-cbz-L-aspartic acid A-(2,6-dichloro-*benzoyloxy;N-CBZ-L-ASPARTIC ACID A-(2 6-DICHLORO- &;INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITOR III;N-CBZ-L-aspartic acid alpha-[(2,6-dichlorobenzoyloxy)....;Z-L-Asp α-([2,6-dichlorobenzoyloxy]methyl ketone);CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE;ICE INHIBITOR V;ICE INHIBITOR VI | | CAS: | 153088-73-4 | | MF: | C20H17Cl2NO7 | | MW: | 454.26 | | EINECS: | | | Product Categories: | Pepetides;peptides;Caspase/Related Products | | Mol File: | 153088-73-4.mol |  |
| | Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Chemical Properties |
| Boiling point | 674.2±55.0 °C(Predicted) | | density | 1.440±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | Soluble in DMSO (up to 25 mg/ml). | | form | White to off-white powder. | | pka | 4.01±0.19(Predicted) | | color | white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| | Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Usage And Synthesis |
| Description | Z-Asp-CH2-DCB is a peptide originally synthesized for its ability to inactivate the interleukin-1β-converting enzyme, which is the homolog of the C. elegans positive regulator of apoptosis CED-3. Z-Asp-CH2-DCB has been shown to block apoptosis by nonselectively inhibiting caspase activity. At 1-100 μM, it can dose-dependently block the production of IL-1β, TNF-α, IL-6, and IFN-γ by human peripheral blood mononuclear cells as well as inhibit T cell proliferation. | | Uses | Z-Asp-2,6-dichlorobenzoyloxymethylketone is a broad Caspase Inhibitor. | | References | 1) Dolle et al. (1994) P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta-converting enzyme; J.Med.Chem. 37 563 |
| | Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Preparation Products And Raw materials |
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