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Tris Base

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Company Name: Yunbio Tech Co.,Ltd.
Tel: 010-60605551
Email: yunbiochem@126.com
Products Intro: Product Name:Trometamol; Tris
CAS:77-86-1
Purity:98% Package:10g;100g;500g;1kg;5kg;10kg,100kg,1ton Remarks:Buffer
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 86-0551-65418684 18949823763
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Products Intro: Product Name:Tris Base
CAS:77-86-1
Purity:99.9% Package:1KG;25USD
Company Name: BOC Sciences
Tel: 1-631-619-7922
Email: inquiry@bocsci.com
Products Intro: Product Name:Tris(hydroxymethyl)aminomethane
CAS:77-86-1
Purity:>98% Package:1g;USD
Company Name: Jinan Qinmu Fine Chemical Co.,Ltd.
Tel: 18363098612
Email: sales@qinmuchem.com
Products Intro: Product Name:Tris Base
CAS:77-86-1
Purity:0.99 Package:25kgs/Drum
Company Name: Hubei Xindesheng Material Technology Co., Ltd.
Tel: +86-15071057538
Email: vickyzhao@whdschem.com
Products Intro: Product Name:tris hydroxymethyl methyl aminomethane
CAS:77-86-1
Purity:>99%(HPLC)

Lastest Price from Tris Base manufacturers

  • Trometamol
  • US $0.00 / Kg/Drum
  • 2020-12-01
  • CAS:77-86-1
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 200mt
  • TRIS
  • US $25.00 / Kg/Drum
  • 2020-11-28
  • CAS:77-86-1
  • Min. Order: 100KG
  • Purity: 99.5%
  • Supply Ability: 20ton

Related articles

Tris Base Basic information
Chemical Properties Uses of Biology Uses
Product Name:Tris Base
Synonyms:OmniPur TRIS -CAS 77-86-1 - Calbiochem;Tris Base, Molecular Biology Grade - CAS 77-86-1 - Calbiochem;Tris Base, ULTROL Grade - CAS 77-86-1 - Calbiochem;Tris Buffer, 1.0 M, pH 8.0, Molecular Biology Grade - CAS 77-86-1 - Calbiochem;Tris Buffer, 100 mM, pH 7.4, Molecular Biology Grade - CAS 77-86-1 - Calbiochem;Tris(Hydroxymethyl)aminomethane (Trometamol) high purity;1-[ethyl(hydroxymethyl)amino]ethane-1,2-diol;TRIS,Tromethamine, Trometamol
CAS:77-86-1
MF:C4H11NO3
MW:121.14
EINECS:201-064-4
Product Categories:tris;Pharmaceutical intermediates;API;ACS Grade Buffers;Amino Alcohols;Biological Buffers;Buffers A to Z;Building Blocks;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Buffer;Biochemistry;Reagents for Electrophoresis
Mol File:77-86-1.mol
Tris Base Structure
Tris Base Chemical Properties
Melting point 167-172 °C(lit.)
Boiling point 219-220 °C10 mm Hg(lit.)
density 1,353 g/cm3
vapor pressure 0.0267 hPa (20 °C)
refractive index 1.4170 (estimate)
Fp 219-220°C/10mm
storage temp. 2-8°C
solubility H2O: 4 M at 20 °C, clear, colorless
form crystalline
color white
PH10.5-12.0(4 m in water, 25 °C)
PH Range7 - 9
pka8.1(at 25℃)
Water Solubility 550 g/L (25 ºC)
λmaxλ: 260 nm Amax: 0.10
λ: 280 nm Amax: 0.08
Sensitive Hygroscopic
Merck 14,9772
BRN 741883
Stability:Stable. Incompatible with bases, strong oxidizing agents. Protect from moisture.
InChIKeyLENZDBCJOHFCAS-UHFFFAOYSA-N
CAS DataBase Reference77-86-1(CAS DataBase Reference)
NIST Chemistry Reference1,3-Propanediol, 2-amino-2-(hydroxymethyl)-(77-86-1)
EPA Substance Registry SystemTris(hydroxymethyl)aminomethane (77-86-1)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39-24/25-23
WGK Germany 2
RTECS TY2900000
3
TSCA Yes
HazardClass IRRITANT
HS Code 29221980
Hazardous Substances Data77-86-1(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rat > 5000 mg/kg
MSDS Information
ProviderLanguage
2-Amino-2-(hydroxymethyl)-1,3-propanediol English
SigmaAldrich English
ACROS English
ALFA English
Tris Base Usage And Synthesis
Chemical PropertiesWhite crystal or powder. Melting point 171-172℃, boiling point 219-220℃/1.3kPa, soluble in ethanol and water, slightly soluble in ethyl acetate, benzene, insoluble in ether, carbon tetrachloride,copper,aluminum corrosion effects,irritant.
Uses of BiologyTris base, also known as THAM, is widely used as a biological buffer or as a component of buffer formulations such as TAE and TBE buffers. Tris has a pKa of 8.06 and is very useful in the biology and biochemistry lab because it has buffering capabilities in the range of the typical physiological pH of most living organisms (pH 7.0-9.0). Tris has been reported to interfere with the activity of a number of enzymes, it should therefore be used carefully when studying proteins.
Uses1, Tris buffer, only nucleic acids and proteins are widely used as solvents.
2, Tris is used for protein crystal growth under different pH conditions.
3, Tris buffer having a low ionic strength can be used nematode (C. elegans) is formed lamin (lamin) intermediate fibers.
4, Tris is a major component of protein electrophoresis buffer.
5, Tris for the preparation of a surfactant, a vulcanization accelerator, and some drug intermediates.
6, Tris titrated also used as standard.
Chemical PropertiesWhite, crystalline solid. PH (0.1M aqueous solution) 10.6, corrosive to copper, brass, aluminum. Solubility in water 80 g/100 cc (20C). Combustible.
OriginatorTrisaminol,Bellon,France,1964
Usestromethamine can help mask odor in a formulation. It is also used as a buffer, keeping product pH stable.
UsesIn the synthesis of surface-active agents, vulcanization accelerators, pharmaceuticals. As emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, leather dressings, textile specialties, polishes, cleaning Compounds, so-called soluble oils. Absorbent for acidic gases. Biological buffer.
Manufacturing ProcessNitromethane is reacted with formaldehyde to give tris(hydroxymethyl)nitromethane in an initial step. This intermediate may be reduced by catalytic hydrogenation (US Patent 2,174,242) or by electrolytic reduction (US Patent 2,485,982).
Brand nameTham (Hospira).
Therapeutic FunctionAntacid
Biological ActivityCommonly used laboratory reagent
Purification MethodsTRIS can ordinarily be obtained in highly pure form suitable for use as an acidimetric standard. If only impure material is available, it should be crystallised from 20% EtOH, aqueous MeOH (m 171.1o) or isopropanol (m 172-173o). Dry it in a vacuum desiccator over P2O5 or CaCl2. Alternatively, it is dissolved in twice its weight of water at 55-60o, filtered, concentrated to half its volume and poured slowly, with stirring, into about twice its volume of EtOH. The crystals which separate on cooling to 3-4o are filtered off, washed with a little MeOH, air dried by suction, then finally ground and dried in a vacuum desiccator over P2O5. It has also been recrystallised from water, MeOH or aqueous MeOH, and vacuum dried at 80o for 2 days. [Beilstein 4 H 303, 4 III 857, 4 IV 1903.]
Tris Base Preparation Products And Raw materials
Raw materialsMethanol-->Potassium carbonate-->Palladium-->Paraformaldehyde-->Nitromethane-->Tris(hydroxymethyl)nitromethane-->Hydrogen-->Formaldehyde
Tag:Tris Base(77-86-1) Related Product Information
N,N-Dimethyl-1,4-phenylenediamine ALTRENOGEST Lithium bis(trimethylsilyl)amide 4,4'-Methylenedianiline Tris(hydroxymethyl)nitromethane Tris Base TROMETAMOL HYDROCHLORIDE Betaine Glycine 2-METHYL-1,3-PROPANEDIOL 1,1,1-Tris(hydroxymethyl)ethane 1,3-Propanediol methylol cellulose 2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol 2-Hydroxyethyl methacrylate 3-Amino-1,2-propanediol BUFFER SOLUTION PH = 6,00 (20 °C) (POTASSIUM DIHYDROGEN PHOSPHATE/SODIUM HYDROXIDE) Hydroxymethyl