ASTX660 manufacturers
- ASTX660
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- $76.00 / 1mg
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2025-06-01
- CAS:1799328-86-1
- Min. Order:
- Purity: 98.33%
- Supply Ability: 10g
- ASTX660
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- $0.00 / 100MG
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2025-03-16
- CAS:1799328-86-1
- Min. Order: 1MG
- Purity: 98
- Supply Ability: 100G
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| | ASTX660 Basic information |
| Product Name: | ASTX660 | | Synonyms: | ASTX660
(ASTX 660;ASTX660;Ethanone, 1-[6-[(4-fluorophenyl)methyl]-2,3-dihydro-5-(hydroxymethyl)-3,3-dimethyl-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methyl-4-morpholinyl]methyl]-1-piperazinyl]-;ASTX660(Tolinapant）;1-(6-(4-Fluorobenzyl)-5-(hydroxymethyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-((2R,5R)-5-methyl-2-(((R)-3-methylmorpholino)methyl)piperazin-1-yl)ethanone;Inhibitor,inhibit,ASTX-660,ASTX660,IAP,ASTX 660;Tolinapant;Tolinapant (ASTX660) | | CAS: | 1799328-86-1 | | MF: | C30H42FN5O3 | | MW: | 539.68 | | EINECS: | | | Product Categories: | API | | Mol File: | 1799328-86-1.mol |  |
| | ASTX660 Chemical Properties |
| Boiling point | 716.6±60.0 °C(Predicted) | | density | 1.169±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:75.0(Max Conc. mg/mL);138.97(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);185.29(Max Conc. mM) | | form | A solid | | pka | 13.30±0.10(Predicted) | | color | White to off-white |
| | ASTX660 Usage And Synthesis |
| Uses | Tolinapant (ASTX660) is an orally bioavailable dual antagonist of cellular inhibitor of apoptosis protein (cIAP) and X-linked inhibitor of apoptosis protein (XIAP). | | in vivo | In HCC1806 xenografts in mice, Tolinapant (daily oral treatment) causes moderate tumor growth inhibition but not regression[1]. | | References | [1] Tomoko Smyth, et al. Abstract 1287: The dual IAP antagonist, ASTX660, increases the anti-tumor activity of NSC 125973 in preclinical models of triple-negative breast cancer in vivo. Cancer Res 2016;76(14 Suppl). |
| | ASTX660 Preparation Products And Raw materials |
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