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| | O-Benzylhydroxylamine hydrochloride Basic information |
| | O-Benzylhydroxylamine hydrochloride Chemical Properties |
| Melting point | 238 °C (subl.)(lit.) | | storage temp. | Inert atmosphere,2-8°C | | solubility | Soluble in DMSO and methanol. | | form | Crystalline Powder or Flakes | | color | White to almost white | | PH | 2.2～3.2 (10g/l, 25℃) | | Sensitive | Hygroscopic | | BRN | 3595440 | | InChI | InChI=1S/C7H9NO.ClH/c8-9-6-7-4-2-1-3-5-7;/h1-5H,6,8H2;1H | | InChIKey | HYDZPXNVHXJHBG-UHFFFAOYSA-N | | SMILES | C1(CON)=CC=CC=C1.Cl | | CAS DataBase Reference | 2687-43-6(CAS DataBase Reference) |
| | O-Benzylhydroxylamine hydrochloride Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powde | | Uses | O-Benzylhydroxylamine hydrochloride is a reagent used for the synthesis of hydroxylamines and hydroxyamates. | | Uses | For use in the formation of nitrones from carbonyl compounds and their use in cycloaddition reactions. Used as a reagent used in the synthesis of hydroxylamines and hydroxyamates. Effective reagent used to prepare α-hydroxybenzylamines from α-hydroxyketones. | | Synthesis | Add the O-benzylacetoxime to a mixed solution of 17 g of methanol and 200 g of a 38% mass concentration hydrochloric acid solution; react for 210 minutes at a temperature of 36°C and a stirring speed of 90 rpm; then distill under reduced pressure at a temperature of 65°C until a solid precipitate out, and cool to room temperature. The solid was washed with petroleum ether (100mL×3) and dried under vacuum at 80°C for 8 hours to obtain 95.18g of the target product O-Benzylhydroxylamine hydrochloride, with a purity of 99.87%; the yield is 98.72%.
 | | Purification Methods | Recrystallise the hydrochloride from H2O or EtOH. [Beilstein 6 IV 2562.] |
| | O-Benzylhydroxylamine hydrochloride Preparation Products And Raw materials |
| Raw materials | 2-Propanone, O-(phenylmethyl)oxime-->Imidodicarbonic acid, 2-(phenylmethoxy)-, 1,3-bis(1,1-dimethylethyl) ester-->Acetamide, N-(phenylmethoxy)--->THIOCHROMAN-4-ONE-->N-Benzyloxybenzamide-->2-Butanone oxime-->O-Benzylhydroxylamine-->2-phenylmethoxyisoindole-1,3-dione-->Benzyl chloride | | Preparation Products | 2,3-DIPHENYLMALEIC ANHYDRIDE-->(S)-ethyl 4-(chloromethyl)-11,11-dimethyl-9-oxo-1-phenyl-2,10-dioxa-3,8-diazadodec-3-ene-7-carboxylate-->Carbamic acid, (phenylmethoxy)-, phenyl ester-->ETHYL 2-(BENZYLOXYAMINO)ACETATE |
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