| Company Name: |
ApexBio Technology LLC
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| Tel: |
+1-832-696-8203 |
| Email: |
info@apexbt.com |
| Products Intro: |
Product Name:Apoptosis Inhibitor
CAS:54135-60-3
Package:10Mg
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2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE) manufacturers
- M50054
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- $55.00 / 5mg
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2025-04-27
- CAS:54135-60-3
- Min. Order:
- Purity: 97.80%
- Supply Ability: 10g
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| | 2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE) Basic information |
| Product Name: | 2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE) | | Synonyms: | M50054;2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE);2,2-METHYLENEBIS-(1,3-CYCLOHEXANEDIONE);2,2'-METHYLENE BIS CYCLOHEXANE-1,3-DIONE;2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione;Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem;1,3-Cyclohexanedione, 2,2'-methylenebis-;Apoptosis,Alopecia,Hepatitis,chemotherapy,Inhibitor,M50054,Caspase-3,Etoposide,Fas,M-50054,anti-Fas,M 50054,inhibit | | CAS: | 54135-60-3 | | MF: | C13H16O4 | | MW: | 236.26 | | EINECS: | 258-989-1 | | Product Categories: | Inhibitor | | Mol File: | 54135-60-3.mol |  |
| | 2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE) Chemical Properties |
| Melting point | 132.5-133.5 °C | | Boiling point | 461.2±40.0 °C(Predicted) | | density | 1.227±0.06 g/cm3(Predicted) | | storage temp. | +2C to +8C | | solubility | Soluble in DMSO or ethanol | | form | Off-white solid | | pka | 4.87±0.25(Predicted) | | color | off-white | | Sensitive | Light Sensitive |
| | 2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE) Usage And Synthesis |
| Uses | A cell-permeable inhibitor of apoptosis induction. Inhibits caspase-3 activation but does not directly inhibit caspase-3 even at 1 mg/ml. | | Definition | ChEBI: 2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione is a beta-diketone. | | Biological Activity | m50054, 2,2'-methylenebis (1,3-cyclohexanedione), is a novel inhibitor of apoptosis. [1]in human fas-expressing wc8 cells, m50054 inhibited apoptosis by soluble human fas ligand in vitro cell death assay. m50054 inhibited the apoptotic u937 cell death which is a human monocytic leukemic cell line, induced by anticancer agents such as etoposide. m50054 inhibited apoptotic characters such as dna phosphatidylserine and fragmentation exposure in these cells. these anti-apoptotic effects were dependent on inhibition of caspase-3 activation. additionally, m50054 significantly inhibited anti-fas-antibody-induced elevation of plasma aspartate aminotransferase and alanine aminotransferase. alopecia (hair loss) symptoms were also significantly improved with topical treatment with m50054. m50054 inhibits apoptosis induced by a variety of stimuli via inhibition of caspase-3 activation, and may thus be effective for hepatitis and chemotherapy-induced alopecia. [1] | | in vivo | M50054 (10-300 mg/kg; oral administration 30 min before anti-Fas antibody injection) inhibits the elevation of alanine aminotransferase and aspartate aminotransferase in a dose-dependent manner[1].
M50054 (topical treatment; given daily beginning on day 5 after birth and ending on day 14) significantly improves alopecia (hair loss) symptoms[1]. | Animal Model: | Female BALB/c mice[1] | | Dosage: | 10, 30, 100 or 300 mg/kg | | Administration: | Orally administered in a volume of 10 mL/kg | | Result: | Inhibited the elevation of alanine aminotransferase and aspartate aminotransferase in a dose-dependent manner.
Significantly improved these parameters at doses of 100 mg/kg and 300 mg/kg.
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| Animal Model: | Five-day-old SD rats[1] | | Dosage: | | | Administration: | Topically applied to the head and back of 5-day-old rats once daily for 10 days | | Result: | Alopecia scores significantly decreased throughout the entire observation period compared with the control group. |
| | target | Caspase | | references | tsuda t, ohmori y, muramatsu h et al. inhibitory effect of m50054, a novel inhibitor of apoptosis, on anti-fas-antibody-induced hepatitis and chemotherapy-induced alopecia.eur j pharmacol. 2001 dec 14;433(1):37-45. |
| | 2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE) Preparation Products And Raw materials |
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