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Epichlorohydrin

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Related articles

  • The Application of Epichlorohydrin
  • Epichlorohydrin is manufactured from allyl chloride and is widely used as a chemical intermediate. A major use is in the synth....
  • Oct 19,2021
Epichlorohydrin Basic information
Description Chemical Properties Uses Environmental Fate References
Product Name:Epichlorohydrin
Synonyms:(chloromethyl)ethyleneoxide;(chloromethyl)-oxiran;New product 99.9% purity CAS 106-89-8 Epichlorohydrin CAS NO.106-89-8 Manufacturers wholesale;γ-Chloropropyleneoxide;CHLOROMETHYLOXIRANE;EPICHLOROHYDRINE;EPICHLORHYDRIN;G-CHLOROPROPYLENE OXIDE
CAS:106-89-8
MF:C3H5ClO
MW:92.52
EINECS:203-439-8
Product Categories:Chlorepoxypropane (Epichlorohydrin);Organics;Oxiranes;Simple 3-Membered Ring Compounds;Building Blocks;Pharmaceutical Intermedaites;organic chemical;Chemical Synthesis;Epoxides;Organic Building Blocks;Oxygen Compounds
Mol File:106-89-8.mol
Epichlorohydrin Structure
Epichlorohydrin Chemical Properties
Melting point -57 °C
Boiling point 115-117 °C(lit.)
alpha -1~+1°(D/20℃)(c=1,CH3OH)
density 1.183 g/mL at 25 °C(lit.)
vapor density 3.2 (vs air)
vapor pressure 13.8 mm Hg ( 21.1 °C)
refractive index n20/D 1.438(lit.)
Fp 93 °F
storage temp. Store below +30°C.
solubility 65.9g/l
form Liquid
Specific Gravity1.183 (20/4℃)
color APHA: ≤20
OdorPungent, garlic; sweet, pungent; like chloroform.
explosive limit3.8-21%(V)
Water Solubility 6 g/100 mL (10 ºC)
FreezingPoint -57.2℃
Merck 14,3611
BRN 79785
Henry's Law Constant3.42(x 10-5 atm?m3/mol) at 25 °C (static headspace-GC, Welke et al., 1998)
Exposure limitsTLV-TWA(skin) 8 mg/m3 (2 ppm) (ACGIH); STEL (15 min) 19 mg/m3 (5 ppm) (NIOSH).
Stability:Stability Unstable. Flammable - note wide explosion limits and low flash point. Vapours may flow along surfaces to source of ignition. Contact with strong oxidisers may lead to fire. Incompatible with strong acids, strong bases, strong oxidizing agents, metal salts, amines, aluminium, chlorine and a variety of chlorine compounds, most com
CAS DataBase Reference106-89-8(CAS DataBase Reference)
NIST Chemistry ReferenceOxirane, (chloromethyl)-(106-89-8)
IARC2A (Vol. 11, Sup 7, 71) 1999
EPA Substance Registry SystemEpichlorohydrin (106-89-8)
Safety Information
Hazard Codes T
Risk Statements 45-10-23/24/25-34-43
Safety Statements 53-45
RIDADR UN 2023 6.1/PG 2
WGK Germany 3
RTECS TX4900000
Autoignition Temperature779 °F
TSCA Yes
HS Code 2910 30 00
HazardClass 6.1
PackingGroup II
Hazardous Substances Data106-89-8(Hazardous Substances Data)
ToxicityLD50 orally in rats: 0.09 g/kg (Smyth, Carpenter)
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
Epichlorohydrin Usage And Synthesis
DescriptionEpichlorohydrin is a kind of organochlorine compound as well as epoxide. It can be used as an industrial solvent. It is a highly reactive compound, and can be used for the production of glycerol, plastics, epoxy glues and resins, and elastomers. It can also be used for the production of glycidyl nitrate and alkali chloride, used as the solvent of cellulose, resins, and paint as well as being used as an insect fumigant. In biochemistry, it can be used as a crosslinking agent for the production of Sephdex size-exclusion chromatography resins. However, it is a potential carcinogen, and can cause various kinds of side effects on respiratory tract and kidneys. It can be manufactured through the reaction between allyl chloride with hypochlorous acid as well as alcohols.
Chemical PropertiesEpichlorohydrin (molecular weight = 92.53 g/mol) is a colorless liquid with a sweet or garlic-like pungent odor. It is soluble in water (6.6 × 104 mg/l at 25 °C) and miscible with most organic solvents.
UsesEpichlorohydrin is mainly used in the production of epoxy resins. It was also used as a solvent for paints, varnishes, lacquers, cellulose esters and ethers, and gums. Epichlorohydrin was historically used as an insecticide fumigant.
Environmental FateEpichlorohydrin may be found in the environment as a result of release in waste streams of resin, paint and lacquer, cellulose ester/ether, and gum production. The high vapor pressure of epichlorohydrin maintains it as a gas in the atmosphere, where it is degraded by photochemically produced hydroxyl radicals (half-life=36 days). Epichlorohydrin is highly mobile in soil, evaporates quickly from dry soil, and is extensively hydrolyzed in moist soil and water. It is not expected to be adsorbed to sediments and suspended particles and is not expected to bioaccumulate in aquatic organisms(NLM, 2013).
Referenceshttps://en.wikipedia.org/wiki/Epichlorohydrin
https://pubchem.ncbi.nlm.nih.gov/compound/epichlorohydrin#section=Top
DescriptionEpoxy resins of the bisphenol A type are synthesized from epichlorhydrin and bisphenol A. This leads to bisphenol-A diglycidyl ether, which is the monomer of bisphenol-A-based epoxy resins. Sensitization to epichlorhydrin occurs mainly in workers in the epoxy-resin industry. Sensitization in individuals not working at epoxy resin plants is rare. It has however been described to occur after contact with a soil fumigant, due to solvent cement and in a worker in a pharmaceutical plant, in a division for drug synthesis. Epichlorhydrin was used for the production of both drugs propranolol and oxprenolol.
Chemical PropertiesEpichlorohydrin is a colorless liquid with a slightly irritating, chloroform-like odor.
Physical propertiesClear, colorless, mobile liquid with a strong, irritating, chloroform-like odor. Odor threshold concentration is 0.93 ppm (quoted, Amoore and Hautala, 1983).
UsesEpichlorohydrin is used to make glycerol,epoxy resins, adhesive, and castings; asderivatives for producing dyes, pharmaceu-ticals, surfactants, and plasticizers; and asa solvent for resins, gums, paints, andvarnishes.
UsesCommercially the most important use is production of glycerine. Large volumes are consumed in nonglycerine areas, which largely consist of the various epoxy resins. It has use as a solvent and in the production of epichlorohydrin rubber.
UsesSolvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for Celluloid. As stabilizer.
DefinitionChEBI: An epoxide that is 1,2-epoxypropene in which one of the methyl hydrogens is substituted by chlorine.
Production MethodsEpichlorohydrin can be prepared from 1,3-dichloropropanol-2, 2,3- dichloropropanol-1, or allyl chloride. Commercially it is prepared as an intermediate in glycerol synthesis via alkaline hydrolysis of glycerol dichlorohydrin. Both come from allyl chloride. Epichlorohydrin reacts with monohydric alcohols to give ethers by opening the oxide ring. It will react with ethers, aldehydes, ketones, organic acids and amines to give a wide variety of useful syntheses.
Synthesis Reference(s)Organic Syntheses, Coll. Vol. 2, p. 256, 1943
The Journal of Organic Chemistry, 48, p. 3831, 1983 DOI: 10.1021/jo00169a052
General DescriptionA clear colorless liquid with an irritating chloroform-like odor. Density 9.8 lb / gal. Flash point 87°F. Polymerizable. If polymerization takes place inside a closed container, the container is subject to violent rupture. Irritates the skin and respiratory system. Toxic by ingestion. A confirmed carcinogen. Vapors heavier than air. Used to make plastics and as a solvent.
Air & Water ReactionsHighly flammable. Water soluble.
Reactivity ProfileEpichlorohydrin may polymerize exothermically if heated or contaminated. Reacts explosively with aniline. Ignites on contact with potassium tert-butoxide. Reacts with trichloroethylene to give the explosive dichloroacetylene. Violent reaction with sulfuric acid or isopropylamine. Exothermic polymerization on contact with strong acids or bases, zinc, aluminum, aluminum chloride, iron, ferric chloride [Sax, 9th ed., 1996, p. 1469].
HazardToxic by inhalation, ingestion, and skin absorption; strong irritant, a carcinogen. Flammable, moderate fire risk. TLV: 0.5 ppm; animal carcinogen.
Health HazardEpichlorohydrin is toxic, carcinogenic, and astrong irritant. Its vapors can produce irrita-tion in the eyes, skin, and respiratory tract.Exposure to high concentration resulted indeath in animals, injuring the central nervoussystem. The liquid can absorb through humanskin, causing painful irritation of subcuta-neous tissues (ACGIH 1986). The symptomsof toxicity from high dosage in test animalswere paralysis of muscles and slow devel-opment of respiratory distress. Long expo-sures at 120 ppm for several hours resultedin lung, kidney, and liver injury in rats(Gage 1959). Ingestion by an oral routecaused tremor, somnolence, and ataxia inmice (NIOSH 1986). The toxic symptomsand lethal doses varied widely with animalspecies. The toxic metabolite of epichlorhy-drin could be ?- chlorohydrin ; thelatter was produced in vitro by rat livermicrosomes (Gingell et al. 1987).
A 25 ppm concentration may be detectableby odor. Exposure at this level may causeburning of the eyes and nose in humans.Above 100 ppm even a short exposure maybe hazardous to humans, causing nausea,dyspnea, lung edema, and kidney injury.
Epichlorohydrin is mutagenic and hasshown carcinogenicity in test animals. Itcaused tumors in the lungs and nose andat gastrointestinal and endocrine sites. Expo-sure to this compound caused harmful repro-ductive effects on fertility and birth defectsin mice.
Health HazardEpichlorohydrin is caustic as both a liquid and gas. Irritation of the eyes and skin, and skin sensitization has been observed. Exposure to epichlorohydrin has caused inflammation of the lungs, asthmatic bronchitis, and liver and kidney damage. In acute poisonings, death may be caused by respiratory paralysis.
Fire HazardWhen heated to decomposition, Epichlorohydrin evolves highly toxic fumes of phosgene and carbon monoxide. Reactive and incompatible with strong oxidizers, strong acids, caustics, zinc, aluminum, chlorides of iron and aluminumand compounds with an active hydrogen atom, including water. Unstable, avoid heat, contaminants, strong acids and bases, certain curing agents such as ethylenediamine. Hazardous polymerization may occur.
Chemical ReactivityReactivity with Water Mild reaction; not likely to be hazardous; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Can polymerize in presence of strong acids and bases, particularly when hot; Inhibitor of Polymerization: None used.
Contact allergensEpoxy resin of the Bisphenol A type is synthesized from epichlorhydrin and bisphenol A. It leads to bisphenol A diglycidyl ether, which is the monomer ofbisphenol-A-based epoxy resins. Sensitization to epichlorhydrin occurs mainly in workers of the epoxy resin industry. Sensitization in individuals not working at epoxy resin plants is rare. It has, however, been described to occur following exposure to a soil fumigant, due to solvent cement, and in a worker in a pharmaceutical plant, in a division of drug synthesis. Epichlorhydrin was used for the production of drugs propranolol and oxprenolol.
Safety ProfileConfirmed carcinogen with experimental carcinogenic data. Poison by ingestion, skin contact, intravenous, and intraperitoneal routes. Moderately toxic by inhalation. An experimental teratogen. Other experimental reproductive effects. Human systemic effects by inhalation: respiratory, nose, and eyes. Human mutation data reported. A skin and eye irritant. A sensitizer. Flammable liquid when exposed to heat or flame. Explosive reaction with andine. Reaction with trichloroethylene forms the explosive dichloroacetylene. Ignition on contact with potassium tertbutoxide. Violent reaction with sulfuric acid or isopropylamine. Exothermic polymerization on contact with strong acids, caustic alkalies, aluminum, aluminum chloride, iron(II1) chloride, or zinc. When heated to decomposition it emits toxic fumes of Cl
Potential ExposureEpichlorohydrin, an organochlorine, is used in the manufacture of many glycerol and glycidol derivatives and epoxy resins; as a stabilizer in chlorine-containing materials; as an intermediate in the preparation of cellulose esters and ethers, paints, varnishes, nail enamels, and lacquers; as a cement for celluloid. It is used as an intermediate in the manufacture of various drugs. Increased cancer risk.
CarcinogenicityEpichlorohydrin is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental fateBiological. Bridié et al. (1979) reported BOD and COD values of 0.03 and 1.16 g/g using filtered effluent from a biological sanitary waste treatment plant. These values were determined using a standard dilution method at 20 °C for a period of 5 d. When a sewage seed was used in a separate screening test, a BOD value of 0.16 g/g was obtained. The ThOD for epichlorohydrin is 1.21 g/g.
Chemical/Physical. Anticipated products from the reaction of epichlorohydrin with ozone or OH radicals in the atmosphere are formaldehyde, glyoxylic acid, and ClCH2O(O)OHCHO (Cupitt, 1980). Haag and Yao (1992) reported a calculated OH radical rate constant in water of 2.9 x 108/M?sec.
storageEpichlorohydrin is stored in a well-ventilated,cool place isolated from combustible andoxidizable materials, all acids and bases,and anhydrous metal halides. Protect fromphysical damage. It is shipped in metaldrums.
ShippingUN2023 Epichlorhydrin, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 3-Flammable liquid.
Purification MethodsDistil epichlorohydrin under atmospheric pressure, heat it on a steam bath with one-quarter its weight of CaO, then decant and fractionally distil it. [Beilstein 17 V 20.]
Toxicity evaluationEpichlorohydrin is an alkylating agent that is mutagenic. It may induce DNA interstrand cross-links, chromosomal aberrations, and breaks. It is also an irritant, sensitizer, and corrosive.
IncompatibilitiesMay form explosive mixture with air. Slowly decomposes on contact with water. Heat or strong acids; alkalies, metallic halides, or contaminants can cause explosive polymerization. Violent reaction with strong oxidizers, aliphatic amines; alkanolamines, amines (especially aniline), alkaline earths; chemically active metals (chlorides of aluminum, iron zinc); powdered metals (aluminum, zinc); alcohols, phenols, organic acids; causing fire and explosion hazard. Will pit steel in the presence of water. Thermal decomposition forms highly toxic phosgene gas. May accumulate static electrical charges, and may cause ignition of its vapors.
Waste DisposalIncineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≧100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal
Epichlorohydrin Preparation Products And Raw materials
Raw materialsSodium hydroxide-->Acetic acid-->Sodium carbonate-->Chlorine-->Calcium carbonate-->Oxygen-->Allyl chloride-->PROPYLENE-->hypochlorous acid-->2-Amino-3-chlorobenzoic acid-->D-D Extender-->2,3-DICHLORO-1-PROPANOL
Preparation Productssoftening agent EST-->3-AMINO-1-PHENOXY-2-PROPANOL HYDROCHLORIDE-->softening agent SCI-A-->noncyanide zinc plating additive-TDAE-->wet strength agent used for paper PAE-->2,3-DIHYDRO-1,4-BENZODIOXIN-2-METHANOL 4-METHYLBENZENESULFONATE-->Ethylene glycol diglycidyl ether-->DL-Carnitine hydrochloride-->1,3,5-Triglycidyl isocyanurate-->zinc plating additive DPE-1-->1-CHLORO-3-FLUOROISOPROPANOL-->CARAZOLOL HCL-->mnocyanide zine plating bright agent-->2-HYDROXYMETHYL-1,4-BENZODIOXANE-->[[p-(2-methoxyethyl)phenoxy]methyl]oxirane-->noncyanide zinc plating additive XD-1-->GLYCIDYL ISOPROPYL ETHER-->ironicion stabilzer-->2-GLYCIDYLOXYBENZONITRILE-->1,4-bis[(3-chloro-2-hydroxypropyl)amino]anthraquinone-->Noncyanide zinc plating additive DE-->Cross-linking agent DE-->BE-strong efficient nickel plating brightener-->Guaiacol glycidyl ether-->2-[(1-Naphthyloxy)methyl]oxirane-->Glycidyl phenyl ether-->N-(4-(OXIRANYLMETHOXY)-1,2-EPOXYPROPANE-->the chelating resin of crosslinking chitosan condense with salilylaldehyde-->Metoprolol-->1,3-diiodopropan-2-ol-->Poly(epichlorohydrin-co-propylene oxide-co-starch)-->noncyanide zinc plating bright additive-->4-(oxiranylmethoxy)-1H-indole-->3-Chloro-2-hydroxypropyltrimethyl ammonium chloride-->noncyanide zie plating additive XD-2-->1-(2-Hydroxy-3-sulfopropyl)-pyridinium betane-->L-Carnitine hydrochloride-->Acetyl-L-carnitine hydrochloride-->L-Carnitine fumarate
Tag:Epichlorohydrin(106-89-8) Related Product Information
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