- Tocofersolan
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- $5.00 / 1KG
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2024-09-23
- CAS:9002-96-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10000kg
- Tocofersolan
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- $0.00 / 1KG
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2024-09-18
- CAS:9002-96-4
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 30tons/month
- Tocofersolan;TPGS
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- $1500.00 / 1kg
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2024-09-18
- CAS:9002-96-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 2 tons
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| | Tocofersolan Basic information |
| Product Name: | Tocofersolan | | Synonyms: | DL-A-TOCOPHEROL POLYETHYLENE GLYCOL SUCCINATE;DL-ALPHA-TOCOPHEROL POLYETHYLENE GLYCOL SUCCINATE;tocofersolan;2-ethanediyl),.alpha.-[4-[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzoPoly(oxy-1;poly(oxy-1,2-ethanediyl),alpha-(4-((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12;dl-alpha-Tocopherol Polethylene Glycol Succinate;D-α-Tocopheryl polyethylene glycol succinate;Poly(oxy-1,2-ethanediyl), .alpha.-4-(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-(4R,8R)-4,8,12-trimethyltridecyl-2H-1-benzopyran-6-yloxy-1,4-dioxobutyl-.omega.-hydroxy- | | CAS: | 9002-96-4 | | MF: | (C2H4O)nC33H54O5 | | MW: | 0 | | EINECS: | 211-836-2 | | Product Categories: | Other APIs;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 9002-96-4.mol |  |
| | Tocofersolan Chemical Properties |
| Melting point | 34-38°C | | storage temp. | 2-8°C | | solubility | H2O: soluble1g/10 mL, clear to faintly turbid, colorless to faintly yellow | | form | Solid | | color | White to Pale Yellow Waxy | | InChI | InChI=1S/C34H56O6/c1-23(2)12-9-13-24(3)14-10-15-25(4)16-11-20-34(8)21-19-29-28(7)32(26(5)27(6)33(29)40-34)39-31(37)18-17-30(36)38-22-35/h23-25,35H,9-22H2,1-8H3 | | InChIKey | WFWQYXBTWIHIIW-UHFFFAOYSA-N | | SMILES | C(=O)(OC1C(C)=C2CCC(C)(CCCC(CCCC(CCCC(C)C)C)C)OC2=C(C)C=1C)CCC(=O)OCO | | LogP | 9.745 (est) |
| WGK Germany | 2 | | RTECS | TR1581200 | | HS Code | 2936.28.0000 |
| | Tocofersolan Usage And Synthesis |
| Chemical Properties | Vitamin E polyethylene glycol succinate is a synthetic product. It is
available as a white to light-brown, waxy solid and is practically
tasteless. Chemically, it is a mixture composed principally of
monoesterified polyethylene glycol 1000, the diesterified polyethylene
glycol 1000, free polyethylene glycol 1000, and free tocopherol. | | Uses | tocophersolan is an anti-oxidant, this is a water-soluble form of vitamin e. | | Uses | Tocofersolan is a polyethylene glycol derivative of α-Tocopherol (T526125). Tocofersolan is a synthetic water-soluble vitamin E unlike its natural counterpart which are fat soluble. Tocofersolan is used in pediatrics in the treatment vitamin E-deficient cholestatic children. Tocofersolan has potential application as a absorption enhancer in drug delivery systems. Typical batch, n = 21 | | Production Methods | Vitamin E polyethylene glycol succinate is prepared by esterification
of the acid group of crystalline D-a-tocopheryl acid succinate by
polyethylene glycol 1000. | | Pharmaceutical Applications | Vitamin E polyethylene glycol succinate is an esterified vitamin E
(tocopherol) derivative primarily used as a solubilizer or emulsifying
agent because of its surfactant properties. Structurally, it is
amphipathic and hydrophilic, unlike the tocopherols, and therefore
it is a water-soluble derivative that can be used in pharmaceutical
formulations such as capsules, tablets, hot-melt extrusion,
microemulsions, topical products, and parenterals. One of
the most important applications is its use as a vehicle for lipid-based
drug delivery formulations. It can also be used as a source of
vitamin E.
Vitamin E polyethylene glycol succinate has been characterized
with respect to its mechanism of action and studied as a Pglycoprotein
inhibitor. | | Biochem/physiol Actions | D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) also known as vitamin E TPGS, is a therapeutic agent for vitamin E deficiency in children, administered during chronic childhood cholestasis. TPGS exerts anti-tumor activity in MCF-7 and breast cancer cells by downregulating anti-apoptotic proteins. TPGS finds its application as an emulsifier in the preparation of poly(lactic-co-glycolic acid) (PLGA) particles for DNA labelling, produces particles of uniform size, high encapsulation efficiency, increases hydrophilicity and prevents aggregation of particles. | | Safety | Vitamin E polyethylene glycol succinate has been used at levels of
280 mg/capsule in the product Agenerase (amprenavir), which was dosed at 8 capsules (2240mg vitamin E TPGS) per day. An
additional assessment of the safety of vitamin E polyethylene glycol
succinate has been published, which includes a report showing
no-observed-adverse-effect-level (NOAEL) in rats of
1000 mg/kg/day. | | storage | Vitamin E polyethylene glycol succinate is stable at ambient room
temperature for up to 4 years. It reacts with alkalis and acids.
Aqueous solutions of vitamin E polyethylene glycol succinate are
stable over a pH range of 4.5–7.5 and can be further stabilized with
propylene glycol. | | Incompatibilities | Vitamin E polyethylene glycol succinate is incompatible with strong
acids and strong alkalis. | | Regulatory Status | GRAS listed. Included in the FDA Inactive Ingredients Database
(ophthalmic solution or drops; oral capsules, solution, tablet;
topical solution or drops). Included in the Canadian List of
Acceptable Non-medicinal Ingredients. |
| | Tocofersolan Preparation Products And Raw materials |
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