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DIAZOXIDE

DIAZOXIDE Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:DIAZOXIDE
CAS:364-98-7
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:364-98-7
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:DIAZOXIDE
CAS:364-98-7
Purity:98% Package:1ASSAYS;1USD
Company Name: hdzhl biotechnology co., ltd
Tel: 86-13032617415
Email: sales@luchibiology.com
Products Intro: Product Name:Diazoxide API
CAS:364-98-7
Purity:99% Package:500g/Bag;USD
Company Name: Hebei Aicrowe Biotech Co., Ltd
Tel: 0311-66855331
Email: aicrowe@kf-chem.com
Products Intro: Product Name:Diazoxided
CAS:364-98-7
Purity:99% Package:1KG;1USD

Lastest Price from DIAZOXIDE manufacturers

  • Diazoxide API
  • US $0.00 / g/Bag
  • 2019-07-22
  • CAS:364-98-7
  • Min. Order: 10g
  • Purity: 99%
  • Supply Ability: 80kg
  • DIAZOXIDE
  • US $1.00 / ASSAYS
  • 2019-07-10
  • CAS:364-98-7
  • Min. Order: 1ASSAYS
  • Purity: 98%
  • Supply Ability: 1kg,2kg,100kg
  • Diazoxided
  • US $1.00 / KG
  • 2019-05-16
  • CAS:364-98-7
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 500
DIAZOXIDE Basic information
Product Name:DIAZOXIDE
Synonyms:DIAZOXIDE 364-98-7 kf-wang(at)kf-chem.com;Diazoxide API;DIAZOXIDE ACTIVATOR OF ATP-DEPE;Diazoxided;Eudemine;hyperstat;DIAZOXIDE,USP;NSC-64198
CAS:364-98-7
MF:C8H7ClN2O2S
MW:230.67
EINECS:206-668-1
Product Categories:Potassium channel;Ion Channels;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;ALCLOXA
Mol File:364-98-7.mol
DIAZOXIDE Structure
DIAZOXIDE Chemical Properties
Melting point >310°C
density 1.3767 (rough estimate)
refractive index 1.6300 (estimate)
storage temp. Store at RT
solubility 0.1 M NaOH: soluble
pkapKa 8.5 (Uncertain)
form neat
Water Solubility Soluble in 0.1M NaOH. Insoluble in water or in methanol.
λmax268nm(MeOH)(lit.)
Merck 14,3004
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 22-26-36
WGK Germany 3
RTECS DK8185000
HS Code 2934990002
MSDS Information
ProviderLanguage
SigmaAldrich English
DIAZOXIDE Usage And Synthesis
Chemical PropertiesWhite Solid
Useswound healing agent
UsesDiazoxide reduces status epilepticus neuron damage in diabetes.
DefinitionChEBI: A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the oncentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Brand nameHyperstat (Schering); Proglycem (Baker Norton).
Biological FunctionsDiazoxide (Hyperstat) is chemically similar to the thiazide diuretics. It is devoid of diuretic activity and causes Na+ and water retention. Diazoxide is a very potent vasodilator and is available only for intravenous use in the treatment of hypertensive emergencies. The mechanism by which diazoxide relaxes vascular smooth muscle is related to its ability to activate potassium channels and produce a hyperpolarization of the cell membrane.
General DescriptionDiazoxide is 7-chloro-3-methyl-4H-benzo[e][1,2,4]thiadiazine-1,1-dioxide , and is currentlyavailable in the United States only as a 50-mg/mLoral suspension (Proglycem); discontinued formulations includedcapsules for oral administration, and injectable formsthat typically found use for indications other than hypoglycemicconditions. Diazoxide is a cyclic benzenesulfonamide,although the free acid in solution can exist in threetautomeric forms, and the 4H tautomer most likely predominatesto a very high proportion. Partly because of theadditional nitrogen in the quinazoline ring structure, themolecule is somewhat more acidic (pKa~8.4, 8.6)than benzenesulfonamide (pKa~10).
General DescriptionDiazoxide is used as the sodium salt of7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide(Hyperstat IV). Diazoxide lowers peripheral vascular resistance,increases cardiac output, and does not compromiserenal blood flow.
This is a des-sulfamoyl analog of the benzothiazine diureticsand has a close structural similarity to chlorothiazide. Itwas developed intentionally to increase the antihypertensiveaction of the thiazides and to minimize the diuretic effect.
Biological ActivityAntihypertensive, activates ATP-dependent K + channels. Induces activation of PKC ε , an intermediate in the opening of mitoK ATP channels, results in cardioprotection against hypoxia-induced death. Blocks desensitization of AMPA receptors.
PharmacologyThe hemodynamic effects of diazoxide are similar to those of hydralazine and minoxidil. It produces direct relaxation of arteriolar smooth muscle with little effect on capacitance beds. Since it does not impair cardiovascular reflexes, orthostasis is not a problem. Its administration is, however, associated with a reflex increase in cardiac output that partially counters its antihypertensive effects. Propranolol and other -blockers potentiate the vasodilating properties of the drug. Diazoxide has no direct action on the heart. Although renal blood flow and glomerular filtration may fall transiently, they generally return to predrug levels within an hour.
Clinical UseDiazoxide is used by intravenous injection as a rapidly acting antihypertensiveagent for emergency reduction of blood pressurein hospitalized patients with accelerated or malignanthypertension. More than 90% is bound to serum protein, andcaution is needed when it is used in conjunction with otherprotein-bound drugs that may be displaced by diazoxide.The injection is given rapidly by the intravenous route toensure maximal effect. The initial dose is usually 1 mg/kg ofbody weight, with a second dose given if the first injectiondoes not lower blood pressure satisfactorily within 30 minutes.Further doses may be given at 4- to 24-hour intervalsif needed. Oral antihypertensive therapy is begun as soon aspossible.
Clinical UseIn contrast to the acute clinical uses of glucagon, diazoxidefinds use in chronic hypoglycemic conditions: inoperableislet cell adenoma or carcinomas, extrapancreatic malignanciesof insulin-secreting cells, or islet cell hyperplasias. Inchildren, additional indications include congenital hyperinsulinemia124and leucine sensitivity. Experimentally, diazoxideis among an array of ATP-sensitive potassium channel openersbeing studied for intermittently bringing aboutβ-cell rest.
Side effectsSince diazoxide is not often used for long-term treatment, toxicities associated with chronic use are rare.The chief concern is the side effects associated with the increased workload on the heart, which may precipitate myocardial ischemia and Na+ and water retention. These undesirable effects can be controlled by concurrent therapy with a β-blocker and a diuretic.
Diazoxide may cause hyperglycemia, especially in diabetics, so if the drug is used for several days, blood glucose levels should be measured. When used in the treatment of toxemia, diazoxide may stop labor, because it relaxes uterine smooth muscle.
Veterinary Drugs and TreatmentsOral diazoxide is used in canine and ferret medicine for the treatment of hypoglycemia secondary to hyperinsulin secretion (e.g., insulinoma). Insulinomas are apparently very rare in the cat; there is little experience with this drug in that species.
In human medicine, intravenous diazoxide is sometimes used for treating severe hypertension.
MetabolismDiazoxide lowers blood pressure within 3 to 5 minutes after rapid intravenous injection, and its duration of action may be 4 to 12 hours. Interestingly, if diazoxide is either injected slowly or infused its hypotensive action is quite modest.This is believed to be due to a rapid and extensive binding of the drug to plasma proteins. Both the liver and kidney contribute to its metabolism and excretion.The plasma half-life is therefore prolonged in patients with chronic renal failure.
DIAZOXIDE Preparation Products And Raw materials
Raw materialsBenzenesulfonamide
Tag:DIAZOXIDE(364-98-7) Related Product Information
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