- 4-POBN
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- $53.00 / 500mg
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2025-11-04
- CAS:5351-17-7
- Min. Order:
- Purity: 99.88%
- Supply Ability: 10g
- 4-Aminobenzohydrazide
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- $1.00 / 1KG
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2019-07-06
- CAS:5351-17-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: Customized
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| | 4-Aminobenzohydrazide Basic information |
| | 4-Aminobenzohydrazide Chemical Properties |
| Melting point | 225-227 °C (lit.) | | Boiling point | 273.17°C (rough estimate) | | density | 1.2100 (rough estimate) | | refractive index | 1.5860 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMF: 10 mg/ml; DMSO: 14 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml | | form | Crystals or Powder | | pka | 13.05±0.10(Predicted) | | color | White or beige | | Water Solubility | Soluble in DMSO (10 mg/ml), dilute acids, and water (partly miscible). | | BRN | 639053 | | CAS DataBase Reference | 5351-17-7(CAS DataBase Reference) | | NIST Chemistry Reference | Benzoic acid, 4-amino-, hydrazide(5351-17-7) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | DG2580000 | | HazardClass | IRRITANT | | HS Code | 29280000 |
| | 4-Aminobenzohydrazide Usage And Synthesis |
| Description | 4-Aminobenzoic acid hydrazide (4-ABAH) is an irreversible inhibitor of myeloperoxidase (MPO; IC50 = 0.3 μM). It reduces the production of hypochlorous acid (HOCl) induced by opsonized zymosan or phorbol 12-myristate 13-acetate (PMA; ) in isolated human neutrophils with IC50 values of 16 and 2.2 μM, respectively. 4-ABAH inhibits PMA-induced formation of neutrophil extracellular traps (NETs) in the same cells. It reduces infarct volume and the severity of neurological deficits, as well as increases survival, in a mouse model of cerebral ischemia induced by transient middle cerebral artery occlusion (MCAO) when administered at a dose of 40 mg/kg twice per day. | | Chemical Properties | White or beige crystals or powder | | Uses | 4-Aminobenzoic hydrazide can be used as a reactant to synthesize:
- Acylhydrazone Schiff base ligand by condensation reaction with 2-acetylpyridine.
- Oligomeric transition metal complexes applicable in the fabrication of organic-inorganic hybrid devices with efficient electrical and photoelectrical properties.
- Oxovanadium(IV)-hydrazide complex as a potential radical scavenger.
| | Uses | 4-Aminobenzhydrazide has an important role in the peroxidation activity of MPO. It is also used in enzyme preparations and in cell cultures. | | References | [1] A J KETTLE. Inhibition of myeloperoxidase by benzoic acid hydrazides.[J]. Biochemical Journal, 1995, 308 ( Pt 2): 559-563. DOI: 10.1042/bj3080559
[2] SHUICHIRO NAKABO. Activated neutrophil carbamylates albumin via the release of myeloperoxidase and reactive oxygen species regardless of NETosis.[J]. Modern Rheumatology, 2020, 30 2: 345-349. DOI: 10.1080/14397595.2019.1583819
[3] REZA FORGHANI. Myeloperoxidase propagates damage and is a potential therapeutic target for subacute stroke.[J]. Journal of cerebral blood flow and metabolism?: official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015: 485-493. DOI: 10.1038/jcbfm.2014.222
[4] RINA KIM. Ferroptosis of tumour neutrophils causes immune suppression in cancer[J]. Nature, 2022, 612 7939: 338-346. DOI: 10.1038/s41586-022-05443-0 |
| | 4-Aminobenzohydrazide Preparation Products And Raw materials |
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