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8-Hydroxyquinoline Suppliers list
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Products Intro: Product Name:8-Hydroxyquinoline
Purity:0.99 Package:5KG;1KG
Company Name: Zhengzhou Yuanli Biological Technology Co., Ltd
Tel: 0086-371-67897895
Products Intro: Product Name:8-Hydroxyquinoline
Purity:0.95 Package:As per customer requirements
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 86-0551-65418684 18949823763
Products Intro: Product Name:8-Hydroxyquinoline
Purity:99.9% Package:1KG;5USD
Company Name: Tangshan Moneide Trading Co., Ltd.
Tel: 86-315-8309571 15633399667
Products Intro: Product Name:8-Hydroxyquinoline
Purity:99.5% min. Package:500g;1kg;25kg
Company Name: Career Henan Chemica Co
Tel: 0371-86658258
Products Intro: Product Name:8-Hydroxyquinoline
Purity:above 99% Package:1g;2USD

Lastest Price from 8-Hydroxyquinoline manufacturers

  • 8-Hydroxyquinoline
  • US $20.00 / KG
  • 2021-07-22
  • CAS:148-24-3
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 50000kg
  • 8-Hydroxyquinoline
  • US $15.00-10.00 / KG
  • 2021-07-13
  • CAS:148-24-3
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton

Related articles

8-Hydroxyquinoline Chemical Properties
Melting point 70-73 °C(lit.)
Boiling point 267 °C752 mm Hg(lit.)
density 1.0340
refractive index 1.4500 (estimate)
Fp 267°C
storage temp. Store at RT.
solubility 0.56g/l
pka5.017(at 20℃)
form Liquid
color White to pale yellow or light beige
Water Solubility INSOLUBLE
Sensitive Light Sensitive
Merck 14,4843
BRN 114512
CAS DataBase Reference148-24-3(CAS DataBase Reference)
NIST Chemistry Reference8-Quinolinol(148-24-3)
IARC3 (Vol. 13, Sup 7) 1987
EPA Substance Registry System8-Quinolinol (148-24-3)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-68-36/37/38
Safety Statements 45-36/37/39-26-36
WGK Germany 3
RTECS VC4200000
Hazard Note Harmful/Irritant
HazardClass 9
PackingGroup III
HS Code 29334990
Hazardous Substances Data148-24-3(Hazardous Substances Data)
ToxicityAn LD50 value of 1,200mg/kg was reported for oral administration of 8-hydroxyquinoline to rats (straidsex unspecified; AAPCO, 1966);a value of 48 mg/kg was reported for intraperitoneal administration to mice (strain/sex unspecxed; Bernstein et al., 1963).
MSDS Information
8-Quinolinol English
SigmaAldrich English
ACROS English
ALFA English
8-Hydroxyquinoline Usage And Synthesis
Chemical Properties8-Hydroxyquinoline is a white to cream-colored crystal or crystalline powder that is insoluble in water or ether and freely soluble in ethanol, acetone, chloroform, benzene, and aqueous mineral acids. It readily forms stable metal chelates, which are soluble or precipitable in organic solvents, depending on the pH of the solution (Hollingshead, 1954).
UsesOxine is an almost universal complexing agent; it reacts with very many metal ions to give water-insoluble precipitates. It has been used so far for the determination of aluminium, antimony, beryllium, bismuth, cadmium, cerium, cobalt, chromium, copper, gallium, germanium, lanthanum, lithium, magnesium, manganese, molybdenum, nickel, ruthenium, thorium, titanium, uranium, vanadium, tungsten, zinc and zirconium.
With the exception of the aluminium, bismuth, gallium, indium, lead and thallium complexes, the oxinate precipitates contain water of crystallization. The majority of the complexes are of stoichiometric composition (either with or without water of crystallization), and therefore subsequent to drying at suitable temperature the precipitates are ready for direct weighing. The precipitates containing water of crystallization are usually dried at 100-105°C and weighed as such, or dried at 130-140°C when the water of crystallization is eliminated.
The complexes can be decomposed with strong acids, and the oxine liberated in an amount equivalent to the metal may be determined by bromatometric titration.
The electrically neutral oxinate complexes are sparingly soluble in water whereas they readily dissolve in apolar solvents immiscible with water, for instance chloroform. Hence this ligand is useful for the solvent extraction enrichment and the subsequent spectrophotometric determination of metal ions. The optimum pH range for complex formation is dependent upon the stabilities of the oxinate complexes. Accordingly, divalent metals are usually precipitated quantitatively in neutral or slightly alkaline media. Adjustment of the suitable pH may be made with various tartrate buffers, for example with ammonia-ammonium tartrate in the pH range 6-10, and with sodium hydroxidesodium tartrate buffers for the pH range 10-13. Complexes of tri- and tetravalent metals are more stable, and thus can be precipitated quantitatively even at about pH 4. In these cases the pH of the solution is adjusted to the desired value with acetic acid-sodium acetate buffers. The copper(II) and iron(III) complexes precipitate quantitatively even at pH 2.7, as does vanadium(V) as an oxinate complex of uncertain composition.
Uses8-Hydroxyquinoline has a wide variety of uses. Primarily because of their metal chelating properties, 8-hydroxyquinoline and its salts, halogenated derivatives, and metal complexes have been used as analytical reagents (Hollingshead, 1954) and as antimicrobial agents in medicine, fungicides, and insecticides (Harvey, 1975). It is also used as a preservative in cosmetics and tobacco, a chemical intermediate in dye synthesis (IARC, 1977), and a precipitating reagent for uranium and other radioactive metals in nuclear power plant liquid waste effluent. It is used in nuclear medicine with indium-111 (Davis et al., 1978).
8-Hydroxyquinoline may be used as a chelating ligand in the preparation of tris-(8-hydroxyquinoline)aluminum (Alq3), an organic electroluminescent compound used in organic light-emitting devices (OLEDs).
DefinitionChEBI: A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.
Manufacturing ProcessThe mixture of 1.4 kg o-nitrophenol, 2.1 kg o-aminophenol, 6 kg glycerine (d = 1.26) and 5 kg sulfuric acid (d = 1.848) was heated at reflux to temperature 130°-140°C. This temperature was kept for 1.5 hours. The obtained oxyquinoline precipitated, the liquid was removed with water-steam distillation. The residue was diluted with water and alkalized with sodium hydroxide and sodium carbonate to the strong alkaline reaction. The repeated distillation with water steam gave the oil, which hardened as the long needles by cooling. MP: 75°-76°C recrystallized from diluted ethanol.
In practice it is usually used as sulfate salt
Brand nameAci-jel;Benzease;Chinosol;Cp-cap;Dermacid;Dermoplast;Fennosan h 30;Heriat;Hydroxybenoxopyridine;Medicone derma-hc;Oxykin;Oxyquinoline-rhp;Pedivol;Phenopyridine;Preconsol;Quinoderm;Quinoped;Quinophenol;Recta medicone-hc;Semori;Serohinol;Serorhinol;Superol;Trimo-san;Triva douch powder;Triva jel.
Therapeutic FunctionAntiseptic
World Health Organization (WHO)Halogenated hydroxyquinoline is structurally related to clioquinol. See WHO comment for clioquinol. (Reference: (WHODI) WHO Drug Information, 77.1, 9, 1977)
General DescriptionWhite to off-white or faintly yellow crystalline powder. Phenolic odor.
Air & Water ReactionsInsoluble in water.
Reactivity Profile8-Hydroxyquinoline darkens on exposure to light. 8-Hydroxyquinoline readily forms stable metal chelates. 8-Hydroxyquinoline is incompatible with strong oxidizers. 8-Hydroxyquinoline is also incompatible with many metal ions.
HazardToxic by ingestion. Questionable carcinogen.
Fire HazardFlash point data for 8-Hydroxyquinoline are not available; however, 8-Hydroxyquinoline is probably combustible.
Clinical UseOxine, quinophenol, or oxyquinoline is the parent compoundfrom which the antiprotozoal oxyquinolines havebeen derived. The antibacterial and antifungal properties of oxine and its derivatives, which are believed to result fromthe ability to chelate metal ions, are well known. Aqueoussolutions of acid salts of oxine, particularly the sulfate(Chinosol, Quinosol), in concentrations of 1:3,000 to1:1,000, have been used as topical antiseptics. The substitutionof an iodine atom at the 7-position of 8-hydroxyquinolinesyields compounds with broad-spectrum amebicidalproperties.
Safety ProfilePoison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. Questionable carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Experimental reproductive effects. A central nervous system stimulant. Human mutation data reported. Combustible when exposed to heat or flame. When heated to decomposition it emits hghly toxic fumes of NOx.
Purification MethodsCrystallise oxine from hot EtOH, acetone, pet ether (b 60-80o) or water. Crude oxine can be purified by precipitation of copper oxinate, followed by liberation of free oxine with H2S or by steam distillation after acidification with H2SO4. Store it in the dark. It forms complexes with many metals. [Manske et al. Can J Research 27F 359 1949, Phillips Chem Rev 56 271 1956, Beilstein 21 III/IV 1135, 21/3 V 252.]
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