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(2-Hydroxypropyl)-γ-cyclodextrin

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Company Name: Wuhan Fortuna Chemical Co.,Ltd
Tel: +8618007136271
Email: hk@fortunachem.com
Products Intro: Product Name:(2-Hydroxypropyl)-γ-cyclodextrin
CAS:128446-34-4
Purity:99% Package:1kg;|25kg
Company Name: Shanghai UCHEM Inc.
Tel: +862156762820 +86-13564624040
Email: sales@myuchem.com
Products Intro: Product Name:(2-Hydroxypropyl)-gamma-cyclodextrin
CAS:128446-34-4
Purity:0.98 Package:25g;62USD|100g;196USD
Company Name: Hebei Chuanghai Biotechnology Co,.LTD
Tel: +86-13131129325
Email: sales1@chuanghaibio.com
Products Intro: Product Name:Hydroxypropyl Gamma Cyclodextrin
CAS:128446-34-4
Purity:98% Package:1kg;10.00;USD
Company Name: Watson Biotechnology Co.,Ltd
Tel: +86-18186686046 +86-18186686046
Email: sales01@watsonbiotech.cn
Products Intro: Product Name:(2-Hydroxypropyl)-gamma-cyclodextrin
CAS:128446-34-4
Purity:99% Package:1kg;|25kg;|100kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
Email: info@tianfuchem.com
Products Intro: Product Name:Hydroxypropyl-γ-cyclodextrin
CAS:128446-34-4
Purity:99% Package:25KG;5KG;1KG

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(2-Hydroxypropyl)-γ-cyclodextrin Basic information
Product Name:(2-Hydroxypropyl)-γ-cyclodextrin
Synonyms:g-Cyclodextrin, 2-hydroxypropylethers;Cavasol? W8 HP;(2-Hydroxypropyl)-gamma-cyclodextrin produced by Wacker Chemie AG, Burghausen, Germany;(2-Hydroxypropyl)-gamma-cyclodextrin Produced by Wacker Chemie AG, Burghausen, Germany, Life Science, >=98.0% (HPLC);(2-Hydroxypropyl)-gaMMa-cyclodextrin extent of labeling: 0.6 Molar substitution;HYDROXYPROPYL-GAMMA-CYCLODEXTRIN (HGC) 4 5% W/V SOLUTION IN H2O;HYDROXYPROPYL-GAMMA-CYCLODEXTRIN, MS=0.6;.gamma.-Cyclodextrin, 2-hydroxypropyl ethers
CAS:128446-34-4
MF:C48H80-nO40.(C3H7O)n
MW:0
EINECS:207-166-5
Product Categories:
Mol File:128446-34-4.mol
(2-Hydroxypropyl)-γ-cyclodextrin Structure
(2-Hydroxypropyl)-γ-cyclodextrin Chemical Properties
Melting point 52-55 °C(lit.)
Boiling point 97-98 °C3 mm Hg(lit.)
Fp >230 °F
storage temp. 2-8°C
solubility H2O: soluble450mg/mL
form Solid powder
color white
PH6-9 (2% in H2O)
optical activity[α]20/D +145°, c = 1 in H2O
InChIKeyWZMOWQCNPFDWPA-UHFFFAOYSA-N
CAS DataBase Reference128446-34-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 26-36/37
WGK Germany 3
HS Code 2940000080
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
(2-Hydroxypropyl)-γ-cyclodextrin Usage And Synthesis
Chemical Propertieswhite powder
UsesFor R&D use
General Description(2-Hydroxypropyl)-γ-cyclodextrin belongs to the class of cyclodextrin derivatives, which exhibit a greater extent of solubility in water compared to their parent compounds. It is widely used in parenteral formulations and solid dosage forms to aid in the improvement of their stability, dissolution, bioavailability, etc.
Biological Activity(2-Hydroxypropyl)-γ-cyclodextrin (HPγCD) is a water-soluble alkylated cyclodextrin derivative. It has pharmaceutical potential as it may aid in enhancing the solubility of drugs for oral dosage preparations or formulations. It solubilizes macromolecules, such as cholesterol. It is like β cyclodextrin but solubilizes larger molecules. It favors lysosomes distribution across the cytoplasm and can modulate lysosomal dynamics and participates in lysosomal homeostasis. HPγCD treatment promotes a wide distribution of lysosomes across the cytoplasm in NPC1 patient-derived fibroblasts. In contrast, lysosomes are clustered near the cell center in untreated cells, raising the possibility that HPγCD has the potential to modulate lysosomal dynamics and functions[1]. In the Niemann pick disease model, HPγCD reduces cholesterol accumulation. Industrially produced HPγCD, which is used as a complexing agent in new ophthalmic formulations, is not a single compound but a heterogeneous, complex mixture of homologues and isomers substituted by a variable number of 2-hydroxy-propyl groups at different positions of the sugar moieties[2].
References [1] Ashutosh Singhal. “2-Hydroxypropyl-gamma-cyclodextrin overcomes NPC1 deficiency by enhancing lysosome-ER association and autophagy.” Scientific Reports (2020): 8663.
[2] W Blum . "Determination of 2-hydroxypropyl-γ-cyclodextrin in plasma of cynomolgus monkeys after oral administration by gas chromatography–mass spectrometry.” Journal of Chromatography B: Biomedical Sciences and Applications 720 1 (1998): Pages 171-178.
(2-Hydroxypropyl)-γ-cyclodextrin Preparation Products And Raw materials
Tag:(2-Hydroxypropyl)-γ-cyclodextrin(128446-34-4) Related Product Information
Hydroxypropyl cellulose 2-Hydroxypropyl-β-cyclodextrin TRIMETHYL-BETA-CYCLODEXTRIN Betadex Sulfobutyl Ether Sodium Heptakis-(6-Mercapto-6-deoxy)-beta-Cyclodextrin β-Cyclodextrin beta-Cyclodextrin methyl ethers 2,6-DI-O-METHYL-BETA-CYCLODEXTRIN α-Cyclodextrine gamma-Cyclodextrin Hydroxypropyl methyl cellulose 2-hydroxypropyl-α-cyclodextrin Hydroxypropyl-beta-cyclodextrin Hydroxypropyl methylcellulose phthalate MALTOTETRAOSE MALTOTRIOSE (2-Hydroxypropyl)-γ-cyclodextrin MALTOHEPTAOSE