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Geldanamycin Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Products Intro: Product Name:Geldanamycin
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: CAS:30562-34-6
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Hubei XinRunde Chemical Co., Ltd.
Tel: +8615102730682; +8618874586545
Products Intro: Product Name:Geldanamycin
Purity:99% Package:100g/ bag, 2 kg/ bag, 25kg/ carton or as required Remarks:yellow to orange powder
Company Name: career henan chemical co
Tel: +86-371-86658258
Products Intro: Product Name:Geldanamycin
Purity:99% Package:1KG;7USD
Tel: (323) 306-3136
Products Intro: Product Name:Geldanamycin
Purity:95% Package:10mg;25mg;50mg;100mg;250mg Remarks:Brand: QCC CAT#QG041300

Lastest Price from Geldanamycin manufacturers

  • Geldanamycin
  • US $0.00 / KG
  • 2020-12-04
  • CAS:30562-34-6
  • Min. Order: 100g
  • Purity: 98%+
  • Supply Ability: 100kg
  • geldanamycin 30562-34-6
  • US $15.00 / mg
  • 2020-08-17
  • CAS:30562-34-6
  • Min. Order: 20mg
  • Purity: ≥98%
  • Supply Ability: 1000.00 kgs
  • Geldanamycin
  • US $1.00 / KG
  • 2020-05-08
  • CAS: 30562-34-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 20T
Geldanamycin Basic information
Product Name:Geldanamycin
Synonyms:Geldanamycin from Streptomyces hygroscopicus, ≥98% (HPLC);geldanamycin 30562-34-6;GELDANAMYCIN;NSC-122750; NSC 122750; NSC122750;Geldanamycin (NSC122750);CS-503;Geldanamycin, Streptomyces hygroscopicus - CAS 30562-34-6 - Calbiochem;[(4Z,6E,8R,9R,10Z,12R,13R,14R,16R)-13-Hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaen-9-yl] carbamate;(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-9-[(Aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21(1)-pentene-3,20,22-trione
Product Categories:Inhibitors;antibiotic;Inhibitor;Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Heat Shock Protein 90;Antibiotics;Antibiotics for Research and Experimental Use;Antitumors for Research and Experimental Use;Biochemistry;Macrolides (Antibiotics for Research and Experimental Use);Others (Antibiotics for Research and Experimental Use)
Mol File:30562-34-6.mol
Geldanamycin Structure
Geldanamycin Chemical Properties
Melting point 255 °C
Boiling point 627.87°C (rough estimate)
density 1.2443 (rough estimate)
refractive index 1.5800 (estimate)
Fp 87℃
storage temp. −20°C
solubility DMSO: soluble
form powder
color yellow to orange
CAS DataBase Reference30562-34-6(CAS DataBase Reference)
Safety Information
Hazard Codes T,Xi
Risk Statements 36/37/38
Safety Statements 26-27-36/37/39-24/25
WGK Germany 2
RTECS LX8920000
HS Code 29419090
MSDS Information
SigmaAldrich English
Geldanamycin Usage And Synthesis
Chemical PropertiesYellow to Orange Powder
UsesGeldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. It binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.
UsesGeldanamycin is benzoquinone ansamycin antibiotic isolated from Streptomyces hygroscopicus. It is a potent antitumour metabolite that acts by binding to the 90-kDa heat-shock protein (Hsp90) essential to maintain the conformation, stability, activity and cellular localisation of several key oncogenic proteins such as ERBB2, C-RAF, CDK4, AKT/PKB, steroid hormone receptors, mutant p53, HIF-1α, survivin and telomerase hTERT.
DefinitionChEBI: An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.
Biological ActivitySelectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (K d = 1.2 μ M) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors.
Geldanamycin Preparation Products And Raw materials
Tag:Geldanamycin(30562-34-6) Related Product Information
17-Amino Geldanamycin-13C,15N2 GELDANAMYCIN 95% 17-DESMETHOXY-17-N,N-DIMETHYLAMINOETHYLAMINO-GELDANAMYCIN, HCL,17-N,N-DIMETHYLAMINOETHYLAMINO-17-DEMETHOXY-GELDANAMYCIN, HCL 17-AAG (17-(Allylamino)-17-demethoxygeldanamycin), Geldanamycin derivative, 0.5857kD 18,21-Didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propenylamino)geldanamycin 17-Amino Geldanamycin 17-DIMETHYLAMINOETHYLAMINO-17-DEMETHOXY-GELDANAMYCIN 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin 17-AAG 3-HEXENE-1 6-DIOLE 2-METHOXY-3-METHYL-[1,4]BENZOQUINONE 2-methoxyethyl carbamate herbimycin B N-DECYL ACRYLAMIDE p-Toluquinone N-DECYL METHACRYLAMIDE HYDROXYPROPYLCARBAMATE Geldanamycin