2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid

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2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid Suppliers list
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2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid Basic information
Product Name:2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid
Synonyms:2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid;FAA1 agonist-1;Acetic acid, 2-?[[4-?[(2'-?chloro[1,?1'-?biphenyl]?-?3-?yl)?methoxy]?phenyl]?sulfonyl]?-;GPR40 agonist 4;2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfony...;GPR-40 agonist 4,GPR40 agonist 4;2-[4-({2'-chloro-[1,1'-biphenyl]-3-yl}methoxy)benzenesulfonyl]acetic acid
CAS:2102196-57-4
MF:C21H17ClO5S
MW:416.87
EINECS:
Product Categories:
Mol File:2102196-57-4.mol
2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid Structure
2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid Chemical Properties
Melting point 121 - 123°C
Boiling point 644.4±55.0 °C(Predicted)
density 1.370±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO (Slightly, Sonicated), Methanol (Slightly)
form Solid
pka2.58±0.10(Predicted)
color White to Off-White
Safety Information
MSDS Information
2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid Usage And Synthesis
Uses2-[[4-[(2''-Chloro[1,1''-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic Acid, is a potent free fatty acid receptor 1 (FFA1/ GPR40) agonist with a pEC50 of 7.54.
in vivo

Single oral administration of GPR40 agonist 4 (compound 20) robustly reduces the plasma glucose excursion and enhances insulin secretion during an oral glucose tolerance test (OGTT) in a dose-dependent manner from 1 to 10 mg/kg when GPR40 agonist 4 is dosed 60 min prior to the oral glucose challenge. The area under the curve of blood glucose (AUC0-120min) and blood insulin (AUC0-120min) reveal that the minimum effective dose of GPR40 agonist 4 is 3 mg/kg. The hyperglycemia state is also markedly improved in GPR40 agonist 4 (20 mg/kg) treated group[1].

2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid Preparation Products And Raw materials
Tag:2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid(2102196-57-4) Related Product Information
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