BI8622 manufacturers
- BI8622
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- $297.00 / 5mg
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2025-11-04
- CAS:1875036-74-0
- Min. Order:
- Purity: 98.28%
- Supply Ability: 10g
- BI8622
-
- $297.00 / 5mg
-
2025-08-22
- CAS:1875036-74-0
- Min. Order:
- Purity: 98.28%
- Supply Ability: 10g
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| Product Name: | BI8622 | | Synonyms: | BI8622;BI8622
(BI-8622;4-Pyrimidinecarboxamide, N-[4-(aminomethyl)phenyl]-6-(4-cyano-4-phenyl-1-piperidinyl)-5-methyl- | | CAS: | 1875036-74-0 | | MF: | C25H26N6O | | MW: | 426.51 | | EINECS: | | | Product Categories: | | | Mol File: | 1875036-74-0.mol |  |
| | BI8622 Chemical Properties |
| Boiling point | 632.6±55.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 125 mg/mL (293.08 mM; Need ultrasonic) | | form | Solid | | pka | 11.59±0.70(Predicted) | | color | White to off-white |
| | BI8622 Usage And Synthesis |
| Uses | BI8622 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 3.1 μM[1]. | | Biological Activity | BI8622 is a selective HUWE1 (HECTH9; MULE; ARF-BP1) inhibitor (IC50 = 3.2 μM by HUWE1 HECT-domain auto-ubiquitination assay; IC50 >50 μM against other HECT-domain Ub ligases tested). BI8622 inhibits the degradation of HUWE1 target proteiins, including MCL1 (IC50 = 6.8 μM; UV irradiated HeLa MCL1 transfectants), MIZ1 (10 μM; Ls174T), and TopBP1. BI8622 suppresses Ls174T colony formation (IC50 = 8.4 μM in 5 days) and the growth of three colon carcinoma cell lines (20 μM for 5 days; HCT116, HT29, SW480). | | References | [1] Peter S, et al. Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase. EMBO Mol Med. 2014 Dec;6(12):1525-41. DOI:10.15252/emmm.201403927 |
| | BI8622 Preparation Products And Raw materials |
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