- 3376-24-7
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- $1.00 / 1KG
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2019-07-06
- CAS:3376-24-7
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1kg,5kg,100kg
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| N-TERT-BUTYL-ALPHA-PHENYLNITRONE Basic information |
| N-TERT-BUTYL-ALPHA-PHENYLNITRONE Chemical Properties |
Safety Statements | 22-24/25 | WGK Germany | 3 | RTECS | TX1760000 | F | 10 | TSCA | Yes | HS Code | 2929 90 00 |
| N-TERT-BUTYL-ALPHA-PHENYLNITRONE Usage And Synthesis |
Chemical Properties | white to light beige fine crystalline powder | Uses | N-tert-Butyl-α-phenylnitrone has been used:
- as a component of Dneasy Blood&Tissue buffer to preserve the oxidized state of DNA extracted from human non-tumorigenic epithelial breast (MCF10A) cells
- as a free radical scavenger of reactive oxygen species (ROS) in microglial (MG) cell lines
- to attenuate fibroblast senescence in unstable oral squamous cell carcinomas (GU-OSCC)
| Uses | Spin trap reagent for carbon- or oxygen- or nitrogen-centered free radicals. | Uses | N-tert-Butyl-a-phenylnitrone is a commonly-used free radical trap. It contains radical scavenging activity and an ability to inhibit Cox-2 (cyclooxygenase-2). N-tert-Butyl-a-phenylnitrone is an antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. N-tert-Butyl-a-phenylnitrone inhibits lipid peroxidation in rat liver microsomes. It also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species. | Synthesis Reference(s) | Tetrahedron, 48, p. 8677, 1992 DOI: 10.1016/S0040-4020(01)89443-6 | General Description | Most commonly-used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species. | Biochem/physiol Actions | Product does not compete with ATP. | Purification Methods | Crystallise PBN from hexane. It is a free radical trap. [cf Janzen Methods Enzymology 105 188 1984, Beilstein 7 IV 519.] |
| N-TERT-BUTYL-ALPHA-PHENYLNITRONE Preparation Products And Raw materials |
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Tag:N-TERT-BUTYL-ALPHA-PHENYLNITRONE(3376-24-7)
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