- N-Cyclohexyl-2-pyrrolidone
-
- $8.00 / 1KG
-
2025-09-25
- CAS:6837-24-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
|
| | N-Cyclohexyl-2-pyrrolidone Basic information |
| | N-Cyclohexyl-2-pyrrolidone Chemical Properties |
| Melting point | 12 °C | | Boiling point | 154 °C7 mm Hg(lit.) | | density | 1.007 g/mL at 25 °C(lit.) | | vapor pressure | 0.05 mm Hg ( 25 °C) | | refractive index | n20/D 1.499(lit.) | | Fp | >230 °F | | storage temp. | Sealed in dry,Room Temperature | | form | clear liquid | | pka | -0.49±0.20(Predicted) | | color | Colorless to Orange to Green | | Water Solubility | Soluble | | BRN | 121832 | | InChI | InChI=1S/C10H17NO/c12-10-7-4-8-11(10)9-5-2-1-3-6-9/h9H,1-8H2 | | InChIKey | PZYDAVFRVJXFHS-UHFFFAOYSA-N | | SMILES | N1(C2CCCCC2)CCCC1=O | | CAS DataBase Reference | 6837-24-7(CAS DataBase Reference) | | EPA Substance Registry System | 2-Pyrrolidinone, 1-cyclohexyl- (6837-24-7) |
| | N-Cyclohexyl-2-pyrrolidone Usage And Synthesis |
| Chemical Properties | clear liquid | | Safety Profile | Poison by ingestion.
Moderately toxic by inhalation and slun
contact. A severe skin and eye irritant. When
heated to decomposition it emits toxic
fumes of NOx. | | Synthesis | Bis[(4-chlorophenyl)methyl](4-chloro-3-butynyl)amine (5) (31.8 mg, 0.090 mmol) was used as a raw material and reacted with rhodium trifluoroacetate dimer (Rh2(tfa)4, 1.18 mg, 0.018 mmol) under argon protection in a mixed solvent of toluene (1.0 mL) and water (0.01 mL) at a heated reflux for 10 hr. After the reaction was completed, the mixture was cooled down. After completion of the reaction, the mixture was cooled to room temperature and filtered through a short diatomaceous earth pad assisted with ethyl acetate. The filtrates were combined and concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent: hexane-ethyl acetate mixed solvent) to give N-cyclohexylpyrrolidone (15.5 mg, 82% yield) as a final oil. The structure of the product was confirmed by 1H NMR, 13C NMR and IR: 1H NMR (δ, ppm): 2.01 (quintuple peak, J = 7.7 Hz, 2H), 2.45 (t, J = 7.7 Hz, 2H), 3.26 (t, J = 7.7 Hz, 2H), 4.42 (s, 2H), 7.18 (d, J = 8.4 Hz, 2H), 7.30 ( d, J = 8.4 Hz, 2H); 13C NMR (δ, ppm): 17.78, 30.81, 46.02, 66.60, 128.87 (2C), 129.51 (2C), 133.51, 135.22, 174.97; IR (pure, cm-1): 3060, 3049, 2926, 1682 (C=O) , 1493, 1093, 1016, 802. | | References | [1] Tetrahedron Letters, 2011, vol. 52, # 19, p. 2458 - 2461 |
| | N-Cyclohexyl-2-pyrrolidone Preparation Products And Raw materials |
|