| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:InSolution eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem
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| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
|
| Products Intro: |
Product Name:InSolution eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem
CAS:304475-63-6
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| | eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem Basic information |
| | eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem Chemical Properties |
| density | 1.474±0.06 g/cm3(Predicted) | | pka | 10.70±0.70(Predicted) |
| | eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem Usage And Synthesis |
| General Description | A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 ~15 μM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC50 ~3 μM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo. The solid form of this compound (Cat. No. 324895) is also available. | | Biochem/physiol Actions | Cell permeable: yes |
| | eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem Preparation Products And Raw materials |
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