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diABZI STING agonist-1 trihydrochloride

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Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:diABZI STING agonist-1 trihydrochloride
CAS:2138299-34-8
Purity:98% Package:5mg Remarks:V31645
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:diABZI STING agonist-1 trihydrochloride
CAS:2138299-34-8
Package:1 mL * 10mM (in DMSO)；10 mg；2 mg；5 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525
Email: masar@topule.com
Products Intro: Product Name:diABZI STING agonist-1 trihydrochloride
CAS:2138299-34-8
Purity:98% Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:diABZI STING agonist-1 trihydrochloride
CAS:2138299-34-8
Purity:98% Package:$214.9/1mg;$450.9/5mg;$750.9/10mg;Bulk package Remarks:98%
Company Name: Wuhan Jingkang en Biomedical Technology Co., Ltd
Tel: +8613720134139
Email: orders@jknbiochem.com
Products Intro: Product Name:STINGagonist-1（compound3）trihydrochloride
CAS:2138299-34-8
Purity:0.98 Package:1G：5G
diABZI STING agonist-1 trihydrochloride Basic information
Product Name:diABZI STING agonist-1 trihydrochloride
Synonyms:diABZI STING agonist-1 trihydrochloride;diABZI STING agonist-1;STING agonist-1（compound 3）trihydrochloride;STING?agonist?diABZ;(E)-1-(4-(5-Carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-morpholinopropoxy)-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-methoxy-1H-benzimidazole-5-carboxamide tris(hydrochloride);diABZI STING Agonist 3 (hydrochloride);STING agonist-1 trihydrochloride;1-[(2E)-4-[5-(Aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-1H-benzimidazole-5-carboxamide Hydrochloride (1:3)
CAS:2138299-34-8
MF:C42H52ClN13O7
MW:886.41
EINECS:
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Mol File:2138299-34-8.mol
diABZI STING agonist-1 trihydrochloride Structure
diABZI STING agonist-1 trihydrochloride Chemical Properties
storage temp. Store at -20°C
solubility DMSO: 50 mg/ml
form A crystalline solid
Safety Information
MSDS Information
diABZI STING agonist-1 trihydrochloride Usage And Synthesis
DescriptiondiABZI STING agonist-1 is an agonist of the stimulator of interferon genes (STING) pathway. It induces secretion of IFN-β in human peripheral blood mononuclear cells (PBMCs; EC50 = 130 nM). diABZI STING agonist-1 (2.5 mg/kg) increases serum levels of IFN-β, IL-6, TNF, and KC/GROα in wild-type, but not Sting-/-, mice. It inhibits the cytopathic effect of the common cold human coronavirus 229E (HCoV-229E) in infected MRC-5 cells (EC50 = 3 nM). diABZI STING agonist-1 also decreases the level of severe acute respiratory coronavirus 2 (SARS-CoV-2) RNA in primary human bronchial airway epithelial cells in an air-liquid interface assay. It decreases tumor volume and increases survival in a CT26 murine colorectal cancer model when administered at a dose of 3 mg/kg.
Uses1-[(2E)-4-[5-(Aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-1H-benzimidazole-5-carboxamide Hydrochloride (1:3), an amino acid derivatve used in preparation of STING protein.
diABZI STING agonist-1 trihydrochloride Preparation Products And Raw materials
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