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STREPTOKINASE

STREPTOKINASE Suppliers list
Company Name: SHANGHAI T&W PHARMACEUTICAL CO., LTD.
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Products Intro: Product Name:Streptokinase
CAS:9002-01-1
Purity:98% Package:Package as requetsed
Company Name: Dideu Industries Group Limited
Tel: 029-88380327; 17691182729
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Products Intro: Product Name:STREPTOKINASE USP/EP/BP
CAS:9002-01-1
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
Company Name: AFINE CHEMICALS LIMITED
Tel: 008657185134551
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Products Intro: Product Name:Streptokinase
CAS:9002-01-1
Purity:98%+ Package:Standard or custom package Remarks:excellent quality and reliable supplier
Company Name: Wuhan wingroup Pharmaceutical Co., Ltd
Tel: 0086-18062075862
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Products Intro: Product Name:MK-8591
CAS:9002-01-1
Purity:99 Package:1KG;1USD
Company Name: Shenzhen Fangye Industries Co., Ltd.  Gold
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Products Intro: Product Name:STREPTOKINASE(Streptokinase)
CAS:9002-01-1
Purity:96,000 IU/mg protein / specific activity Package:bottle Remarks:Storage: Preserve at teMperature between 2 Deg C to 8 Deg C

Lastest Price from STREPTOKINASE manufacturers

  • MK-8591
  • US $1.00 / KG
  • 2021-10-20
  • CAS:9002-01-1
  • Min. Order: 100g
  • Purity: 99
  • Supply Ability: 30tons
STREPTOKINASE Basic information
Product Name:STREPTOKINASE
Synonyms:awelysin;kabikinase;streptase;streptococcalfibrinolysin;strepto-kinase(enzyme-activating;Dickkopf-1;Dickkopf-related protein-1;DKK-1 human
CAS:9002-01-1
MF:C11H19NO2
MW:197.27406
EINECS:232-647-1
Product Categories:enzyme;Streptokinase Bulk Solution;Crude Streptokinase;Refined Streptokinase
Mol File:9002-01-1.mol
STREPTOKINASE Structure
STREPTOKINASE Chemical Properties
storage temp. -20°C
form lyophilized powder
Merck 13,8903
Safety Information
Hazard Codes B,Xi
Risk Statements 36/37/38
Safety Statements 22-24/25-36-26
WGK Germany 3
RTECS OB8880000
10-21
ToxicityLD50 oral in mouse: > 10gm/kg
MSDS Information
ProviderLanguage
SigmaAldrich English
STREPTOKINASE Usage And Synthesis
DescriptionStreptokinase is a protein produced by certain strains of hemolytic group C streptococcus, and it was the first clinically useful fibrinolytic. Unlike other plasminogen activators, streptokinase is not an enzyme and cannot break any bonds in a plasminogen molecule by itself. It forms an equimolecular compound with plasminogen, thus forming a streptokinase–plasminogen complex. In the plasminogenic region of the resulting complex, certain conformational changes lead to a break in a few peptide bonds, and transformation of this complex into a streptokinase–plasmin complex, or free plasmin, which also decomposes fibrin.
OriginatorStreptase,Hoechst,France,1970
UsesThis drug has a half-life in the plasma of 15–30 min, and is used intravenously to treat patients with severe, massive pulmonary embolism and thrombus of the veins; it is also used during myocardial infarctions. Recently, a number of streptokinase derivatives have been proposed, in particular acetylated derivatives, which are developed for use as fibrinolytics.
Therapeutic FunctionEnzyme
General DescriptionStreptokinase (Kabikinase, Streptase)is a catabolic 47,000-d protein secreted by group Cβ-hemolyticstreptococci. It is a protein with no intrinsic enzymaticactivity. Streptokinase activates plasminogen toplasmin, a proteolytic enzyme that hydrolyzes fibrin andpromotes the dissolution of thrombi. Plasminogen is activatedwhen streptokinase forms a 1:1 stoichiometric complexwith it. Allergic reactions to streptokinase occur commonlybecause of antibody formation in individuals treatedwith it. Furthermore, the antibodies inactivate streptokinaseand reduce its ability to prolong thrombin time.Streptokinase is indicated for acute myocardial infarction,for local perfusion of an occluded vessel, and before angiography,by intravenous, intra-arterial, and intracoronaryadministration, respectively.
Mechanism of actionStreptokinase is a protein purified from culture broths of group C β-hemolytic streptococci bacteria. Streptokinase contains a single polypeptide chain of 414-amino-acid residues with a molecular weight of 47 kDa. Streptokinase by itself has no intrinsic enzymatic activity. To be active, it must bind with plasminogen to form an activator complex (1:1 complex). This complex then acts to convert uncomplexed plasminogen to the active fibrinolytic enzyme, plasmin. The streptokinase/plasminogen complex not only degrades fibrin clots but also catalyzes the breakdown of fibrinogen and factors V and VII. As a result, streptokinase is considered to be a fibrinnonspecific drug.
PharmacokineticsUnfortunately, the half-life of the activator complex is less than 30 minutes, which frequently is too short to completely lyse a thrombus. Anistreplase (APSAC; Eminase) is a 1:1 streptokinase/lysineplasminogen complex that has been acylated with an anisoyl group at the active-site serine within the lysine-plasminogen. Anistreplase is inactive as such, but following complexation with fibrin, the anisoyl group is slowly cleaved, exposing the active site and, thus, leading to degradation of fibrin. The pro-drug nature of anistreplase exhibits an improved pharmacokinetic profile, with anistreplase acting as a semiselective lysis agent at the clot site. The inactivity of the circulating anistreplase also allows this drug to be given as a very rapid intravenous infusion (typically, 30 U over 3–5 minutes). Tissue reperfusion following anistreplase therapy compares favorably to streptokinase because of the extended half-life (90 minutes).
Side effectsBecause it is a foreign protein, streptokinase is associated with significant hypersensitivity reactions. Most people have, at some point in their lives, had a streptococcal infection and, therefore, have developed circulating antistreptococcal antibodies. These antibodies frequently are active against streptokinase as well. The response of the streptokinase to these antibodies can vary widely, from inactivation of the fibrinolytic properties of the protein to rash, fever, and rarely, anaphylaxis. Significant allergic reactions to streptokinase occur in approximately 3% of patients.
Veterinary Drugs and TreatmentsStreptokinase may be useful for the adjunctive treatment of serious thromboses. The use of thrombolytics (streptokinase, t-PA) in cats is controversial.
STREPTOKINASE Preparation Products And Raw materials
Raw materialsCalcium phosphate-->Cholesterol
Preparation ProductsStreptodornase/streptokinase
Tag:STREPTOKINASE(9002-01-1) Related Product Information
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