|
|
| | SCH 58261 Basic information |
| Product Name: | SCH 58261 | | Synonyms: | 7H-Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, 2-(2-furanyl)-7-(2-phenylethyl)-;2-(Furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyriMidin-5-aMine;CS-2187;SCH-58261;SCH 58261;4-(furan-2-yl)-10-(2-phenylethyl)-3,5,6,8,10,11-hexaazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2,4,7,11-pentaen-7-amine;4-(furan-2-yl)-10-(2-phenylethyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-7-amine;Butanoicacid,4-bromo-5-oxo-,ethylester;Inhibitor,inhibit,SCH-58261,Adenosine Receptor,SCH 58261,P1 receptor | | CAS: | 160098-96-4 | | MF: | C18H15N7O | | MW: | 345.36 | | EINECS: | | | Product Categories: | Adenosine receptor | | Mol File: | 160098-96-4.mol |  |
| | SCH 58261 Chemical Properties |
| Melting point | 223 °C | | density | 1.54±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | DMSO: >10 mg/mL, soluble | | pka | 2.78±0.30(Predicted) | | form | solid | | color | off-white |
| WGK Germany | 3 | | HS Code | 2934.99.3000 |
| | SCH 58261 Usage And Synthesis |
| Uses | SCH 58261 is a potent and selective A2A adenosine receptor antagonist. | | Definition | ChEBI: LSM-3822 is a member of triazolopyrimidines. | | Biological Activity | Potent and selective A 2A adenosine receptor competitive antagonist (K i = 1.3 nM). Displays 323-, 53- and 100-fold selectivity over A 1 , A 2B and A 3 receptors, respectively. | | Biochem/physiol Actions | SCH 58261 reduces the levels of TNF-α, Fas-L, Bax expression and activation of JNK-MAPK pathway. It has neuroprotective effects as it reduces demyelination of the neurons. SCH 58261 increases the concentration of secretion of dopamine and elicits locomotor sensitization, an attractive option in the possible treatment of Parkinson′s disease. | | storage | Store at RT |
| | SCH 58261 Preparation Products And Raw materials |
|