YKL-5-124

YKL-5-124 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:YKL-5-124
CAS:1957203-01-8
Purity:99.5% Package:1mg;97USD|2mg;137USD|5mg;198USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
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Products Intro: Product Name:YKL-5-124
CAS:1957203-01-8
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: Nantong HI-FUTURE Biology Co., Ltd.
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Products Intro: Product Name:YKL-5-124
CAS:1957203-01-8
Purity:98%+ Package:100MG,500MG,1G,5G,10G 50MG
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525
Email: masar@topule.com
Products Intro: Product Name:YKL-5-124
CAS:1957203-01-8
Purity:98%+ Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
Company Name: Aladdin Scientific
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Email: tp@aladdinsci.com
Products Intro: Product Name:YKL-5-124
CAS:1957203-01-8
Purity:99% Package:$251.9/5mg;Bulk package Remarks:99%

YKL-5-124 manufacturers

  • YKL-5-124
  • YKL-5-124 pictures
  • $97.00 / 1mg
  • 2025-04-27
  • CAS:1957203-01-8
  • Min. Order:
  • Purity: 99.5%
  • Supply Ability: 10g
YKL-5-124 Basic information
Product Name:YKL-5-124
Synonyms:YKL-5-124;Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-[(1S)-2-(dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[[4-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]-;(S)-3-(4-Acrylamidobenzamido)-N-(2-(dimethylamino)-1-phenylethyl)-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide;T-loop,phosphorylation,inhibit,arrest,CDK7,Inhibitor,CDK,YKL5124,YKL 5 124,CDK7/Mat1/CycH,Cyclin dependent kinase,cell-cycle,transcription,Pol-II,irreversible,covalent;YKL-5-124, 10 mM in DMSO
CAS:1957203-01-8
MF:C28H33N7O3
MW:515.61
EINECS:
Product Categories:
Mol File:1957203-01-8.mol
YKL-5-124 Structure
YKL-5-124 Chemical Properties
Boiling point 706.1±60.0 °C(Predicted)
density 1.284±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (484.86 mM; Need ultrasonic)
pka12.78±0.40(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
YKL-5-124 Usage And Synthesis
UsesYKL-5-124 is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively. YKL-5-124 is >100-fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL-5-124 induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status[1].
Biological ActivityYKL-5-124 is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively. YKL-5-124 is >100-fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL-5-124 induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status[1]. YKL-5-124 (0-2000 nM; 72 hours; HAP1 cells) treatment causes a dose-dependent increase in G1- and G2/M-phase cells and a corresponding loss of S-phase cells[1].YKL-5-124 (0-2000 nM; 24 hours; HAP1 WT cells) treatment inhibits CDK1 T-loop phosphorylation, and to a lesser extent CDK2 T-loop phosphorylation in a concentration-dependent fashion[1].Treatment of cells with YKL-5-124 as a competitor at a concentration of about 30 nM blocks pull-down of CDK7-cyclin H but has no effect on the pull-down of cyclin K-CDK12/13 in HAP1 cells. Treatment with 100 nM YKL-5-124 reduces CDK7-cyclin H binding to bioTHZ1 by >50% at 30 min[1].
IC 50CDK7: 53.5 nM (IC50); CDK7/Mat1/CycH: 9.7 nM (IC50); CDK2: 1300 nM (IC50); CDK9: 3020 nM (IC50)
storageStore at -20°C
References[1]. Olson CM, et al. Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype. Cell Chem Biol. 2019 Jun 20;26(6):792-803.e10.
YKL-5-124 Preparation Products And Raw materials
Tag:YKL-5-124(1957203-01-8) Related Product Information
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