|
|
| | β-Endorphin (human) (trifluoroacetate salt) Basic information |
| | β-Endorphin (human) (trifluoroacetate salt) Chemical Properties |
| solubility | Water: 1 mg/ml |
| | β-Endorphin (human) (trifluoroacetate salt) Usage And Synthesis |
| Description | β-Endorphin is an endogenous 31-amino acid neuropeptide and opioid receptor agonist that binds to μ-, δ-, and κ-opioid receptors (Kis = 3.73, 5.02, and 32.7 nM, respectively, in COS-1 cells expressing rat receptors).1 It binds to rat and mouse brain membrane preparations (IC50s = 0.33 and 0.67 nM, respectively) and induces chemotaxis of human monocytes in vitro when used at a concentration of 0.1 pM.2,3,4 Intracerebroventricular administration of β-endorphin increases the latency to tail withdrawal in response to thermal stimuli in mice with a median antinociceptive dose (AD50) value of 27 pmol per animal.2 It also increases preference for the drug-paired place in a conditioned place preference test when administered to rats intracerebroventricularly at a dose of 5 μg.5WARNING This product is not for human or veterinary use. | | References | [1] ALFRED MANSOUR. The cloned μ, δ and κ receptors and their endogenous ligands: Evidence for two opioid peptide recognition cores[J]. Brain Research, 1995, 700 1: Pages 89-98. DOI: 10.1016/0006-8993(95)00928-j
[2] R G HAMMONDS C H L P Nicolas. beta-endorphin-(1-27) is an antagonist of beta-endorphin analgesia.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1984, 81 5: 1389-1390. DOI: 10.1073/pnas.81.5.1389
[3] JAVIER GARZÓN Pilar S B. αN-acetyl derivatives of β-endorphin-(1–31) and -(1–27) regulate the supraspinal antinociceptive activity of different opioids in mice[J]. Life sciences, 1991, 48 14: Pages 1417-1427. DOI: 10.1016/0024-3205(91)90439-i
[4] PAOLA SACERDOTE Alberto E P. Analysis of the beta-endorphin structure-related activity on human monocyte chemotaxis: Importance of the N- and C-terminal[J]. Peptides, 1989, 10 3: Pages 565-569. DOI: 10.1016/0196-9781(89)90143-5
[5] R BALS-KUBIK T S S A Herz. Beta-endorphin-(1-27) is a naturally occurring antagonist of the reinforcing effects of opioids.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 1988, 338 4: 392-396. DOI: 10.1007/bf00172115 |
| | β-Endorphin (human) (trifluoroacetate salt) Preparation Products And Raw materials |
|