2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐

2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐

中文名称2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐
中文同义词2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐;心源醇C 盐酸盐
英文名称4-(2-HYDROXYETHYLAMINO)-2-(4-METHOXYPHENYLAMINO)-PYRIMIDINE HYDROCHLORIDE
英文同义词CARDIOGENOL C HYDROCHLORIDE;4-(2-HYDROXYETHYLAMINO)-2-(4-METHOXYPHENYLAMINO)-PYRIMIDINE HYDROCHLORIDE;2-[[2-[(4-Methoxyphenyl)aMino]-4-pyriMidinyl]aMino]ethanol Hydrochloride;2-[[2-[(4-Methoxyphenyl)amino]-4-pyrimidinyl]amino]ethanol hydrochloride (1:1);Ethanol, 2-[[2-[(4-methoxyphenyl)amino]-4-pyrimidinyl]amino]-, hydrochloride (1:1);Cardiogenol C hydrochloride(b)
CAS号1049741-55-0
分子式C13H17ClN4O2
分子量296.75
EINECS号
相关类别Agonist;Aromatics;Agro Products
Mol文件Mol File
结构式2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐 结构式

2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐 性质

储存条件−20°C
溶解度H2O:10 mg/mL,可溶
形态固体
颜色白色至米白色

2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐 用途与合成方法

Cardiogenol C hydrochloride 是一种有效的细胞渗透性嘧啶诱导剂,可促使 ESCs 分化为心肌细胞 (ESCs differentiation into cardiomyocytes) (EC50=100 nM)。Cardiogenol C hydrochloride 还可以在有限的可塑性范围内对已经沿袭的祖细胞类型产生心肌生成效应。Cardiogenol C hydrochloride 是一种有用的心肌生成试剂,在动物模型中可以用作细胞移植研究中提高心脏修复的工具。

EC50: 100 nM (differentiation of ESCs into cardiomyocytes)

Cardiogenol C hydrochloride (1 μM; 7 days) has a cardiomyogenic effect on P19 cells, it significantly increases atrial natriuretic factor (ANF, nppa ) in P19 cells when it compares to untreated control cells.Cardiogenol C hydrochloride (0.01-100 μM; 7 days) significantly increases ANF expression. In addition, another frequently used cardiac marker gene (NKX2-5) is also significantly increased by this small molecule in C2C12 cells.Cardiogenol C hydrochloride (0.001-100 μM; 7 days) increases cardiac Nav1.5 sodium channel protein expression as dose-dependent manner in C2C12 cells.Cardiogenol C hydrochloride (1 μM; 35 days) addition from day 0 significantly increases myocardial differentiation and results in a significantly increased percentage of CBs with beating cardiomyocytes. This small moleculepromotes the development of beating cardiomyocytes in cardiovascular progenitor cell-derived cardiac bodies.Cardiogenol C hydrochloride (0.01-100 μM; 7 days) does not effect cell growth even at 10 μM. In addition, Cardiogenol C either solves in water or DMSO generates a similar effect. The highest concentration, 100 μM has significant cellular toxicity on C2C12 cells.

RT-PCR

Cell Line: C2C12 cells
Concentration: 0.01 μM; 0.1 μM; 1 μM; 3 μM; 10 μM; 30 μM; 100 μM
Incubation Time: 7 days
Result: Increased ANF and NKX2.5 mRNA level as a dose-dependent manner.

Western Blot Analysis

Cell Line: C2C12 cells
Concentration: 0.001 μM; 0.01 μM; 0.1 μM; 1 μM; 10 μM
Incubation Time: 7 days
Result: Increased cardiac Nav1.5 sodium channel protein levels.

Cell Proliferation Assay

Cell Line: C2C12 cells
Concentration: 0.01 μM; 0.1 μM; 1 μM
Incubation Time: 7 days
Result: Did not exert toxic effects on C2C12 cells at 0.01-10 μM treatment.

安全信息

危险品标志Xi
危险类别码36/37/38
安全说明26-36
WGK Germany3

MSDS信息

提供商 语言
英文
更新日期产品编号产品名称CAS号包装价格
2024/08/19HY-12319A2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐
Cardiogenol C hydrochloride
1049741-55-05mg600元
2024/08/19HY-12319A2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐
Cardiogenol C hydrochloride
1049741-55-010mM * 1mLin DMSO660元

2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐 上下游产品信息

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