2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐
中文名称 | 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐 |
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中文同义词 | 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐;心源醇C 盐酸盐 |
英文名称 | 4-(2-HYDROXYETHYLAMINO)-2-(4-METHOXYPHENYLAMINO)-PYRIMIDINE HYDROCHLORIDE |
英文同义词 | CARDIOGENOL C HYDROCHLORIDE;4-(2-HYDROXYETHYLAMINO)-2-(4-METHOXYPHENYLAMINO)-PYRIMIDINE HYDROCHLORIDE;2-[[2-[(4-Methoxyphenyl)aMino]-4-pyriMidinyl]aMino]ethanol Hydrochloride;2-[[2-[(4-Methoxyphenyl)amino]-4-pyrimidinyl]amino]ethanol hydrochloride (1:1);Ethanol, 2-[[2-[(4-methoxyphenyl)amino]-4-pyrimidinyl]amino]-, hydrochloride (1:1);Cardiogenol C hydrochloride(b) |
CAS号 | 1049741-55-0 |
分子式 | C13H17ClN4O2 |
分子量 | 296.75 |
EINECS号 | |
相关类别 | Agonist;Aromatics;Agro Products |
Mol文件 | Mol File |
结构式 |
2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐 性质
储存条件 | −20°C |
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溶解度 | H2O:10 mg/mL,可溶 |
形态 | 固体 |
颜色 | 白色至米白色 |
EC50: 100 nM (differentiation of ESCs into cardiomyocytes)
Cardiogenol C hydrochloride (1 μM; 7 days) has a cardiomyogenic effect on P19 cells, it significantly increases atrial natriuretic factor (ANF, nppa ) in P19 cells when it compares to untreated control cells.Cardiogenol C hydrochloride (0.01-100 μM; 7 days) significantly increases ANF expression. In addition, another frequently used cardiac marker gene (NKX2-5) is also significantly increased by this small molecule in C2C12 cells.Cardiogenol C hydrochloride (0.001-100 μM; 7 days) increases cardiac Nav1.5 sodium channel protein expression as dose-dependent manner in C2C12 cells.Cardiogenol C hydrochloride (1 μM; 35 days) addition from day 0 significantly increases myocardial differentiation and results in a significantly increased percentage of CBs with beating cardiomyocytes. This small moleculepromotes the development of beating cardiomyocytes in cardiovascular progenitor cell-derived cardiac bodies.Cardiogenol C hydrochloride (0.01-100 μM; 7 days) does not effect cell growth even at 10 μM. In addition, Cardiogenol C either solves in water or DMSO generates a similar effect. The highest concentration, 100 μM has significant cellular toxicity on C2C12 cells.
RT-PCR
Cell Line: | C2C12 cells |
Concentration: | 0.01 μM; 0.1 μM; 1 μM; 3 μM; 10 μM; 30 μM; 100 μM |
Incubation Time: | 7 days |
Result: | Increased ANF and NKX2.5 mRNA level as a dose-dependent manner. |
Western Blot Analysis
Cell Line: | C2C12 cells |
Concentration: | 0.001 μM; 0.01 μM; 0.1 μM; 1 μM; 10 μM |
Incubation Time: | 7 days |
Result: | Increased cardiac Nav1.5 sodium channel protein levels. |
Cell Proliferation Assay
Cell Line: | C2C12 cells |
Concentration: | 0.01 μM; 0.1 μM; 1 μM |
Incubation Time: | 7 days |
Result: | Did not exert toxic effects on C2C12 cells at 0.01-10 μM treatment. |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-12319A | 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐 Cardiogenol C hydrochloride | 1049741-55-0 | 5mg | 600元 |
2024/08/19 | HY-12319A | 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐 Cardiogenol C hydrochloride | 1049741-55-0 | 10mM * 1mLin DMSO | 660元 |