- 2'-FLUORO-D-CYTIDINE
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- $0.00 / 1kg
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2023-04-04
- CAS:10212-20-1
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 500kg per month
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| 2'-Deoxy-2'-fluorocytidine Basic information |
| 2'-Deoxy-2'-fluorocytidine Chemical Properties |
Melting point | 167 °C | Boiling point | 500.1±60.0 °C(Predicted) | density | 1.82±0.1 g/cm3(Predicted) | refractive index | 80 ° (C=1, MeOH) | storage temp. | Keep in dark place,Sealed in dry,2-8°C | solubility | Soluble in DMSO, Methanol. | pka | 12.84±0.70(Predicted) | form | Powder | color | White to Off-white | Water Solubility | Water: 5 mg/mL (20.39 mM; ultrasonic and warming and heat to 60°C) | InChI | InChI=1S/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6-,7-,8-/m1/s1 | InChIKey | NVZFZMCNALTPBY-XVFCMESISA-N | SMILES | OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](F)[C@@H]1O | CAS DataBase Reference | 10212-20-1(CAS DataBase Reference) |
Hazard Codes | Xi | Risk Statements | 36/37/38 | Safety Statements | 26-36 | HS Code | 29389090 |
| 2'-Deoxy-2'-fluorocytidine Usage And Synthesis |
Chemical Properties | White Solid | Uses | 2'-Deoxy-2'-fluorocytidine is a potent inhibitor of the subgenomic hepatitis C virus replicon in Huh-7 cells. 2'-Deoxy-2'-fluorocytidine has been shown to inhibit Borna Disease virus replication and s
pread. | in vitro |
2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells.
| References | [1] Stephen R. Welch. “Identification of 2′-deoxy-2′-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus.” Antiviral research 147 (2017): Pages 91-99.
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| 2'-Deoxy-2'-fluorocytidine Preparation Products And Raw materials |
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